摘要
目的探讨喹诺酮类药物不良反应的发生及相关防治措施。方法回顾性分析2005年6月至2012年1月发生的喹诺酮类药物不良反应155例病例资料。结果 60岁以上患者喹诺酮类药物不良反应发生率最高,占27.10%(42/155);以左氧氟沙星发生的不良反应居多,占38.71%(60/155);静脉给药不良反应发生率最高,占90.97%(141/155);以全身性不良反应发生率最高,占32.90%(51/155),其次为中枢神经系统受累,占20.65%(32/155)。结论喹诺酮类药物不良反应的发生率相对较高,临床医生应合理选择应用。
Objective To investigate the quinolones-caused adverse drug reactions（ADR） and related control measures.Methods The clinical data in 155 cases of ADR caused by quinolones from June 2005 to January 2012 were analyzed retrospectively.Results The incidence rate of quinolones-caused ADR was highest in the patients aged more than 60 years old,accounting for 27.1%（42/155）.Quinolones-caused ADR was dominated by levofloxacin,accounting for 38.71%（60/155）.The incidence rate of ADR by intravenous administration was highest,accounting for 90.97%（141/155）.The incidence rate of systemic ADR was highest,accounting for 32.90%（51/155）,and followed by the central nervous system involvement,accounting for 20.65%（32/155）.Conclusion The occurrence rate of quinolones-caused ADR is relatively higher,so clinical doctors should select and use reasonably.
出处
《现代医药卫生》
2013年第1期27-28,共2页
Journal of Modern Medicine & Health
关键词
喹诺酮类
抗感染药
药用制剂
副作用
药物不良反应
Quinolones
Anti-infective agents
Pharmaceutical preparations/adverse effects
Adverse drug reaction
