摘要
目的 探讨肺栓塞（PE）患者肺灌注缺损百分数测定（PPDS%）的临床价值。方法 回顾36例临床确诊的PE患者资料,依据PPDS%值（低危PPDS%〈30%、中危30%≤PPDS%〈50%、高危PPDS%≥50%）对PE进行危险分层,比较低危、中危、高危PE 的PPDS%及其临床不良事件发生率,对比治疗前后的PPDS%变化。结果 36例患者依据PPDS%值分级为低危15例、中危13例、高危8例,依据2008欧洲心脏病学会（ESC）指南分级为低危16例、中危12例、高危8例,两者的分级一致率为94.4%（34/36）,其中高危患者的分级一致率为100.0%（8/8）。PE治疗前的PPDS%为（46.2±4.6）%,明显高于治疗后［（31.6±1.8）%］（t=17.38,P〈0.01）;低危、中危、高危PE的PPDS%分别为（25.9±3.9）%、（45.6±4.3）%、（58.4±4.9）%（t=6.18,P〈0.01）。低危、中危、高危PE分别有1例（6.5%）、3例（23.0%）、5例（62.5%）发生临床不良事件,差异有统计学意义（χ2=8.71,P〈0.05）。结论 PPDS%可作为PE分级诊断、预后判断及疗效观察的重要参考指标。
Objective To investigate the clinical value of the decfion of percentage of pulmonary perfusion defect score （PPDS%） in patients with pulmonary embolism （PE）.Methods A retrospective study was carried out on PPDs%data of patients（n=36） with clinical confirmed PE.The patients were divided into three levels：low （PPDS%〈30%）,medial （30%≤PPDS%〈50%） and high （PPDS%≥50%） risk groups,according to the standard of PPDs%diagnosis.the PPDS%and the incidence rate of the clinical adverse events were compared in mild,moderate and severe risk PE.The therapeutic results were compared with the PPDS%changes.Results The mild,moderate and severe risk patients with PE were 15 cases,13 cases and 8 cases respectively,according to the standard of PPDS%diagnosis.16 cases,12 cases and 8 cases respectively,according to the standard of 2008 ESC APE diagnosis and treatment guidelines.The uniform rate was 94.4%for two methods,the uniform rate was 100.0%in which high risk of PE.The PPDS%of PE was （46.2±4.6）%before treatment.The data was significantly higher than that post treatment （31.6%±1.8%）（t=17.38,P〈0.01）.The scores of low,medial and high risk patients were （25.9±3.9）%,（45.6±4.3）% and （58.4±4.9）%（t=6.18,P〈0.01）,respectively.The mild,moderate and severe risk PE according to the PPDS%standard with clinical adverse events for were 1 cases（6.5%）,3 cases （23.0%） and 5 cases （62.5%） respectively,with a significant difference（χ2=8.71,P〈0.05）. Conclusion PPDS%could be used as an important reference index for risk stratification of diagnosis,evaluating therapeutic efficiency and predicting the prognosis in patients with PE.
出处
《中国基层医药》
CAS
2013年第1期21-22,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
广东省深圳市科技计划项目（200703127）
关键词
肺栓塞
肺灌注
放射性同位素
危险性评估
Pulmonary embolism
Pulmonary perfusion
Radioisotopes
Risk assessment
