摘要
目的 探讨迷走神经干预对心房电重构的影响及意义。方法 30条杂种犬给予美托洛尔以消除交感神经对心房电重构的影响;观察使用阿托品前、后及心房电重构后高位右心房（SA）和冠状静脉窦（CS）,迷走神经刺激（VS）下或无迷走神经刺激（Non-VS）下的心房有效不应期（ERP）及心房颤动易感窗口（VW）。结果 应用阿托品前,VS后发现ERP显著缩短［（54.83±46.23）ms］,VW显著性增加［（19.86±13.23）ms］,此时心房颤动易于发生;使用阿托品后,VS下的ERP明显延长［（112.33±9.63）ms］,可并未诱发房颤;心房电经过重构后,基础和VS下的ERP与心房电重构前差异均无统计学意义（t=2.116、0.853,均P〉0.05）。结论 VS可加重心房电重构,增加心房颤动易感性;迷走神经阻滞能减轻心房电重构,使心房颤动易感性降低。
Objective To investigate the impact and significance of the vagus nerve intervention on the atrial electrical emodeling.Methods 30 mongrel dogs were given metoprolol in order to eliminate the effects of sympathetic nerve on atrial electrical remodeling;observe the atrial effective refractory period（ERP） and atrial fibrillation susceptible window（VW） in the high right atrial（SA） and coronary sinus（CS） by the vagus nerve stimulation（VS） or vagus nerve stimulation（Non-VS） before and after using atropine and after atrial electrical remodeling was observed.Results Before using vagus nerve blocking agents atropine,ERP shortened significantly [（54.83±46.23）ms]and VW increased significantly [（19.86±13.23）ms]after VS,this time with atrial fibrillation-prone;After using atropine,ERP increased significantly [（112.33±9.63）ms] under VS,did not induce atrial fibrillation;After atrial electrical remodeling,the value of ERP was no significant difference under basis and VS（t=2.116,0.853,all P〉0.05）. Conclusion VS can increase the atrial electrical remodeling,an increase of atrial fibrillation susceptibility;vagus nerve block can reduce atrial electrical remodeling and atrial fibrillation susceptibility decreased.
出处
《中国基层医药》
CAS
2013年第1期16-18,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
广东省中山市科技计划项目（20113A111）
关键词
迷走神经
心房电重构
心房颤动
Vagus nerve
Atrial electrical remodeling
Atrial fibrillation
