摘要
目的:优选山楂叶总黄酮分散片的处方。方法:以表面形态和崩解时限为指标,采用单因素试验优选填充剂和黏合剂;以压片黏冲情况为指标,采用单因素试验优选润滑剂;以崩解时限为指标,采用正交试验优选崩解剂。结果:优选的处方以200片投料量计算,选取90g微晶纤维素为填充剂,以交联聚乙烯吡咯烷酮(2g)和羧甲基淀粉钠(6g)为崩解剂,以80ml水为黏合剂,以1.6g十二烷基硫酸钠为润滑剂。结论:所选处方合理、可行,可为山楂叶总黄酮分散片的制备提供理论依据。
OBJECTIVE： To optimize the prescription of Crataegi Folium flavonoids dispersible tablets. METHODS： Using morphology and disintegration time as index, the filler and binder were optimized in single factor test; single factor test was also used to optimize the lubricant with tablet compressing and sticking as index; the disintegrating agent was optimized by orthogonal experiments with disintegration time as index. RESULTS： By inventory of 200 pieces, microcrystalline cellulose （90 g） was used as filler, crospolyvinylpyrrolidone （2 g） and sodium carboxymethyl starch （6 g） as disintegrating agent, 80 ml water as binder and 1.6 g sodium dodecylsulfate as lubricant. CONCLUSION： The prescription is reasonable and feasible, and it provides reference for the preparation of Crataegi Folium flavonoids dispersible tablets.
出处
《中国药房》
CAS
CSCD
2013年第7期613-615,共3页
China Pharmacy
关键词
山楂叶总黄酮
分散片
处方
Crataegi Folium flavonoids
Dispersible tablets
Prescription
