摘要
目的探讨萘敏维（Naphazoline）联合微量地塞米松在围手术期降低翼状胬肉术后复发的效果。方法翼状胬肉106例（121眼）随机分治疗组和对照组。治疗组（62眼）围手术期行萘敏维联合微量地塞米松滴眼；对照组（59眼）围手术期行妥布霉素滴眼液滴眼。分析比较两组角膜创面愈合时间、结膜充血消退时间和术后〈3个月，3～6个月，7-12个月的翼状胬肉的复发情况。结果角膜创面愈合时间治疗组为（3．67±1．31）d，对照组为（3．25±1．04）d（t=1．947，P〉0．05）。术后结膜炎症充血消退时间治疗组为（15．50±4．45）d，对照组为（21．40±6．78）d（t=5．6855，P〈0．01）。随访〈3个月，治疗组无复发，对照组复发率5．1％（χ2=3．856，P〈0．05）。结论萘敏维联合微量地塞米松在翼状胬肉围手术期应用对炎症反应和复发率有抑制作用。
Objective To explore the effect of Naphazoline ＆ trace dexamethasone in the perioper- ative period of pterygium surgery. Methods 106 cases of pterygium （ 121 eyes） were divided into 2 groups （treatment group and control group ）. Napbazoline ＆ trace dexamethasone were applied in the treatment group （62 eyes）. Tobramycin were applied in the control group （59 eyes）. Corneal epithelial healing time, conjunctival hyperemia subsided time and the recurrence rate of pterygium after operation at different time points were selected as the main outcomes. Results There was no statistical significance between the treat- ment group （3.67 ± 1.31d） and the control group （3.25 ± 1.04d） on the corneal epithelium healing time （ t = 1. 947, P 〉 0.05 ）. Compared with the control group （21.40 ± 6.78d）, conjunctival hyperemia subsi- ded time was shorter in the treatment group （15.50 ±4.45d） , which has statistical significance （t =5.6, P 〈0.01 ）. The rate of recurrence in the treatment group was much lower than that in the control group. The difference reached statistical significance （χ2 = 3. 856, P 〈 0.05）. Conclusion Naphazoline ＆ trace dex- amethasone in the perioperative period of pterygium surgery can effectively control the inflammatory response and reduce the recurrence with high safety.
出处
《中华眼外伤职业眼病杂志》
2013年第2期138-140,共3页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
关键词
萘敏维
地塞米松
翼状胬肉
围手术期
Naphazoline
Dexamethasone
Pterygium
Period, perioperative
