摘要
目的研究添加不同浓度抗生素对玻璃离子水门汀（GIC）抗茵性能和机械性能的影响。方法将三种抗生素以不同浓度加入GIC中，通过琼脂扩散试验观察材料的抗菌性能；利用扫描电镜（SEM）观察材料表面细菌附着状况。测量材料抗压缩强度，评价添加抗生素对材料机械性能的影响。结果琼脂扩散试验及SEM结果显示添加抗生素能够大大提高材料的抗茵性能，且与添加抗生素的浓度成正比。加入抗生素成分后，材料的抗压缩强度明显降低。结论抗生素能增强GIC抑制变形链球菌作用，但机械性能受到影响，在以后的研究中，应探讨通过控释缓释技术以在不影响材料机械性能的同时增强抗菌性能。
Objective To evaluate the effect of different concentrations of antibiotics on antibac- terial effects and physical properties of conventional glass-ionomer cements （GICs）. Methods Fuji IX GIC was used as a control. Different concentrations of three antibiotic mixtures, ciprofloxacin, metron- idazole and minocycline, were added to powdered GIC （Fuji IX） to obtain concentration ratios of 1.5% , 3.0% and 4.5%. The antibacterial activity of each GIC was evaluated against Streptococcus mutans u- sing agar-diffusion methods and scanning electron microscopy （SEM）. The compressive strength were measured and compared with those of control samples. Results All tested groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups （ P 〈 0.05 ）. However, the antibiotics had significantly lower compressive strength than the control group （P 〈 0. 05 ）. Conclusions The GIC-containing antibiotics are effective in inhibiting S. mutans. However, the antibiotics compromised the mechanical properties of the cement.
出处
《中国实用医刊》
2013年第4期4-6,共3页
Chinese Journal of Practical Medicine
