摘要
目的:研究添加不同浓度米诺环素对树脂改良型玻璃离子水门汀(resin-modified glass ionomer cement,RMGIC)抗菌性能和机械性能的影响。方法:将米诺环素以不同浓度加入RMGIC中,通过生物膜实验观察材料的抗菌性能;测量材料抗压缩强度及表面微硬度,评价添加抗菌剂对材料机械性能的影响。结果:生物膜形成实验结果显示添加米诺环素后能够有效提高RMGIC的抗菌性能,且抗菌性能的强弱与添加米诺环素的浓度成正比。加入较高浓度的米诺环素后,材料的抗压缩强度和表面微硬度降低。结论:米诺环素能有效增强RMGIC抑制变形链球菌的作用,但高浓度的米诺环素可使材料的机械性能受到影响。在对牙科充填材料进行抗菌改性的同时应当考虑材料本身的机械性能,选择合适的方法和浓度,以使材料发挥更好的作用。
Objective：To evaluate the antibacterial effects and physical properties of resin-modified glass-ionomer cements（RMGICs） containing minocycline.Methods：RMGIC（Fuji ⅡLC） was used as control.Minocycline was added to powdered RMGIC to obtain concentration ratios of 1.5,3.0 and 4.5% w/w.The antibacterial activity of each RMGIC was evaluated against Streptococcus mutans using biofilm assay.The compressive strength and microhardness were measured and compared with those of control samples.Results：All experimental groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups（P0.05）.However,RMGIC with high concentration minocycline had significantly lower compressive strength and microhardness than the control group（P0.05）.Conclusion：The minocycline-containing RMGIC were effective in inhibiting S.Mutans.However,high concentration minocycline compromised the mechanical properties of the cement.
出处
《口腔医学研究》
CAS
CSCD
2012年第12期1239-1241,共3页
Journal of Oral Science Research
