摘要
目的分析医院2010年10月-2011年10月血培养中主要病原菌及其耐药性,为临床选择抗菌药物提供依据。方法采集怀疑有血液感染的患者血标本,在BACETC 9120全自动血培养仪中培养,培养阳性者用传统方法对细菌进行鉴定,并用K-B法检测细菌的耐药性。结果血培养共分离出细菌258株,革兰阳性菌139株,占53.88%;革兰阴性菌113株,占43.80%;真菌6株,占2.32%,所分离的病原菌中前3位分别为大肠埃希菌、表皮葡萄球菌和金黄色葡萄球菌,表皮葡萄球菌和金黄色葡萄球菌对青霉素、红霉素耐药,对万古霉素敏感;大肠埃希菌对氨苄西林耐药,对哌拉西林、头孢哌酮/舒巴坦和头孢他啶/克拉维酸敏感;真菌对5-氟胞嘧啶耐药,而对两性霉素B、氟康唑、伊曲康唑、酮康唑和制霉菌素敏感。结论血培养中病原菌有较高的耐药率,为提高患者治愈率,应及时了解血培养结果以便临床合理用药。
OBJECTIVE To investigate the distribution and antibiotic resistance of pathogens isolated from blood culture samples from Oct 2010 to Oct 2011,and to provide basis for clinical rational utilization of antibiotics.METHODS The blood samples were collected and cultured by BACETC 9120 automated blood culture system,and the positive samples were identified by the traditional routine procedures.Bacterial susceptibility test were carried out by K-B method.RESULTS A total of 258 strains of pathogens were isolated from blood culture samples,including 139 strains of gram-positive bacteria,113 strains of gram-negative bacteria and 6 strains of fungi.The isolation rates of Escherichia coli（27.52%）,Staphylococcus epidermidis（24.42%） and S.aureus（14.34%） were the highest.S.epidermidis and S.aureus were resistant to penicillin and erythromycin,but susceptible to vancomycin.E.coli strains were resistant to ampicillin,but susceptible to piperacillin,sulperazon and ceftazidime.The fungi were resistant to flucytosine,but susceptible to amphotericin B,fluconazole,itraconazole,ketoconazole,and nystatin.CONCLUSION The blood cultured pathogens are highly drug resistant.It is necessary to understand the blood culture result in a timely manner so as to use antibiotics reasonably and improve the cure rate of the patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第3期695-697,共3页
Chinese Journal of Nosocomiology
关键词
血培养
病原菌
耐药性
Blood culture
Pathogen
Drug resistance
