摘要
目的评价促红细胞生成素(EPO)两种不同给药方式治疗晚期恶性肿瘤化疗所致贫血的临床疗效。方法 60例同期接受全身化疗且伴随肿瘤相关性贫血的晚期恶性肿瘤患者均分为两组:试验组按EPO 60×103 U静脉滴注每周1次;对照组化疗同时采用EPO 10×103 U皮下注射每周3次;均治疗4周。观察治疗2周及4周后的疗效。结果 EPO治疗2周及4周后,两组的Hb、红细胞压积(Hct)和RBC值均较治疗前明显增高(P<0.05),同期试验组各项观察指标均比对照组明显增加(P<0.05)。结论两种给药方式对改善晚期恶性肿瘤化疗所致贫血均有效,静脉给药方式临床疗效更佳。
Objective To evaluate the efficacy of different injection approaches of erythropoietin（EPO） in treating chemotherapy-induced anemia in patients with advanced malignant neoplasms. Methods Sixty patients with chemotherapy-related anemia were equally divided into two groups of A（treated with intravenous infusion of EPO 60×103U once a week for 4 weeks） and B（treated with subcutaneous injection of EPO 10×103U 3 times a week for 4 weeks）. The efficacy on the 2nd and 4th week was compared between two groups. Results After treatment,Hb,HCT and RBC in two groups were increased significantly（P〈0.05） and the increases of Hb,HCT and RBC were more in group A than those in group B（P〈0.05）. Conclusion Compared to subcutaneous injection of EPO 10×103U,intravenous infusion of EPO 60×103U is more effective in treating chemotherapy-induced anemia in patients with advanced malignant neoplasms.
出处
《江苏医药》
CAS
北大核心
2013年第2期199-201,共3页
Jiangsu Medical Journal
