摘要
目的研究胃癌组织中基质细胞因子-1(stromal derived factor-1,SDF-1)及其受体(CXC chemokine receptor 4,CXCR4)的表达,探讨SDF-1/CXCR4轴与血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的关系及其与胃癌浸润转移的相关性。方法采用免疫组织化学法检测62例胃癌患者的胃癌组织及癌旁组织中SDF-1,CXCR4及VEGF的表达情况。结果胃癌组织中SDF-1,CXCR4及VEGF的阳性表达率分别为85.4%,58.1%,62.9%,均高于癌旁组织45.2%,38.7%,35.5%,差异有统计学意义(P<0.05);SDF-1及CXCR4的表达水平在肿瘤病理分级、TNM分期、淋巴结及远处脏器转移上差异有统计学意义(P<0.05);SDF-1,CXCR4的表达与VEGF均呈正相关(r=0.394,P<0.05;r=0.526,P<0.05)。结论 SDF-1/CXCR4轴及VEGF在胃癌的生长、浸润、转移中发挥重要作用,可能成为未来药物治疗胃癌的重要靶点。
Objective To investigate the expressions of stromal derived factor 1 （SDF-1） and CXC ehemokine receptor 4 （CXCR4） and their relationship with vascular endothelial growth factor （VEGF） and metastasis in gastric cancer. Methods The expressions of SDF-1/CXCR4 and VEGF in gastric cancer were detected with immunohistochemistry technique in 62 cases of gastric cancer and adjacent tissues. Results The positive expression rates of SDF 1, CXCR4 and VEGF were 85.4%, 58. 1% and 62.9% in gastric cancer tissues, significantly higher than those in the adjacent tissues （45.2%, 38.7%and 35.5%） （P〈0.05）. There were significant differences in the expressions of SDF 1 and CXCR4 in pathological grades, tumor depthes as well as lymph node and distant metastasis （P〈0.05）. The expression of SDF-1 and CXCR4 were positively correlated with the expression of VEGF in gastric cancer （r= 0. 394, P〈0.05; r= 0. 526, P〈0.05）. Conclusion The expressions of SDF-1/CXCR4 and VEGF play important roles in the formation and metastasis of gastric cancer and may be the potent targets of medicinal therapy in future.
出处
《中华实用诊断与治疗杂志》
2013年第2期131-133,共3页
Journal of Chinese Practical Diagnosis and Therapy
