摘要
以孕烯醇酮为原料,经过PCC氧化、肟化或PCC氧化、NaBH4选择性还原、肟化,合成得到3个文献未见报导的具有不同肟基取代、具有孕甾烷结构的甾体肟类化合物。另外,通过孕烯醇酮和甲氧胺反应,得到了1个孕甾甲氧肟醚化合物。合成产物的结构经NMR和IR表征。另外,体外抗肿瘤细胞生长增值抑制活性测试表明,化合物6具有一定的体外抑制肿瘤细胞生长增值活性。
Three steroidal oximes with various substituted hydroximino group and pregnane structure were synthesized from preg- nenolone by the oxidation of PCC,reduction of NaBH4, and oximation. Furthermore,a methoxyl-oxime ether（7）was obtained by the reaction of pregnenolone with methoxylamine. The structures of synthesized compounds were characterized by NMR and IR. The cy- totoxicity of the compounds against some cancer cells were investigated. The results showed that the compound 6 displayed distinct antiproliferative activity.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2013年第2期220-223,共4页
Chemical Research and Application
基金
广西自然科学基金项目(2010GXNSFD013019)资助
