摘要
The removal of protein bound substances from blood is of therapeutic interest for drug intoxications,renal and liver failure,and so on.Current methods using hemoperfusion over adsorbents or plasma exchange are effective but not specific enough.This work presents a new procedure in which an albumin (BSA) filled porous asymmetric membrane with a high permeable flux is prepared and used for the removal of lipophilic toxins (unconjugated bilirubin) from blood.The transport mechanism of the membrane to remove protein bound toxins is analysed.The transport characteristics of the BSA filled membrane are tested by using aqueous BSA solution containing unconjugated bilirubin as simulated blood in a diffusion cell.In addition,some factors affecting transport rate are discussed.It concludes that the present method provides a theoretical basis for treatment of acute liver failure as well as acute or chronic intoxications with alburnin bound toxins.
The removal of protein bound substances from blood is of therapeutic interest for drug intoxications,renal and liver failure,and so on.Current methods using hemoperfusion over adsorbents or plasma exchange are effective but not specific enough.This work presents a new procedure in which an albumin (BSA) filled porous asymmetric membrane with a high permeable flux is prepared and used for the removal of lipophilic toxins (unconjugated bilirubin) from blood.The transport mechanism of the membrane to remove protein bound toxins is analysed.The transport characteristics of the BSA filled membrane are tested by using aqueous BSA solution containing unconjugated bilirubin as simulated blood in a diffusion cell.In addition,some factors affecting transport rate are discussed.It concludes that the present method provides a theoretical basis for treatment of acute liver failure as well as acute or chronic intoxications with alburnin bound toxins.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2000年第3期403-406,共4页
CIESC Journal
基金
国家自然科学基金!资助项目 (No .2 97760 36)
