摘要
目的研究血浆中micro RNA-122（miR-122）的表达量与肝癌手术前后肝损伤的相关性。方法利用荧光定量检测30名健康人与30例肝癌患者的术前miR-122及丙氨酸氨基转移酶（ALT）的表达量,并进行比较,且检测30例肝癌患者的术前,术后第1、3、7天的血浆中miR-122及ALT,探讨miR-122与ALT的相关性。结果术前肝癌患者血浆中miR-122以及ALT的表达量均显著高于健康人群（P〈0.05）。患者术前,术后第1、3、7天血浆中的miR-122均与ALT呈正相关。结论血浆miR-122与肝切除术肝功能损伤相关,有望成为肝癌肝切除术前后肝功能损伤的检测指标。
Objective To study the correlation between micro RNA-122 （miR-122） expression and liver injury before and after hepatectomy of cancer. Methods MiR-122 and ALT of 30 healthy people and 30 liver cancer patients were detected by fluorogenic quantitative before operation and compared. Also miR-122 and ALT were measured on the first, third and seventh day postoperatively. The correlation between miR-122 and ALT was explored. Results The expression of miR-122 and ALT of plasma of liver cancer patients were remarkably higher than that of health people. MiR-122 of plasma had positive correlation to ALT during the preoperative and postoperative process. Conclusion MiR-122 of plasma has correlation to the damage of hepatectomy of cancer. It could be a detection index of damage before and after hepatectomy of cancer.
出处
《中国当代医药》
2013年第2期98-99,共2页
China Modern Medicine
