摘要
目的以超声引导下肝组织活检病理肝脏纤维化程度分期为标准,分析超声与肝纤维化血清指标单一及二者综合诊断与慢性乙型肝炎肝纤维化病理结果的相关性。方法 142例慢性乙型肝炎者,在超声引导下行肝组织活检,将其病理结果与治疗前超声检查和肝纤维化血清标志物检测结果进行对照分析。结果超声与肝纤维化血清指标综合诊断慢性乙型肝炎肝纤维化与病理结果的敏感性、特异性及准确性分别为81.8%、90.8%和86.6%。结论与病理结果比较,超声分类诊断相对低估了肝纤维化的程度,而血清指标对肝纤维化的病理分期没有直接而明确的分期指导意义。综合分析超声检查和血清肝纤维化标志物检测结果,将提高对慢性乙型肝炎肝纤维化程度的判定力,特别是对可逆转的早期肝硬化的诊断,对病例定期追踪观察、指导治疗及预后与疗效判定有重大意义。
Objective To investigate the correlation between ultrasonography, liver fibrosis biomarkers and pathology in chronic type B hepatitis patients by taking ultrasound - guided liver biopsy results as the standard of liver fibrosis classification. Methods One hundred and forty - two patients with chronic hepatitis type B were enrolled in this study. Liver biopsy was performed after uhrasonography and liver fibrosis biomarkers measurement. The pathological results were compared and analyzed with those of ultrasound and biomarkers. Results Compared with pathological results, the sensitivity, specificity and accuracy of ultrasound combined with biomarkers in diagnosis of liver fobrosis were 81. 8%, 90. 8% and 86. 6% , respectively. Conclusion Combination of uhrasonography and liver fibrosis biomarkers measurement can improve the evaluation of liver fibrosis, especially severe liver fibrosis or early cirrhosis. It is an important method for case follow up, treatment guidance and prognosis judgment.
出处
《临床超声医学杂志》
2011年第7期455-458,共4页
Journal of Clinical Ultrasound in Medicine
关键词
慢性乙型肝炎
肝纤维化
超声检查
血清标志物
Chronic type B hepatitis
Liver fibrosis
Uhrasonography
Serum biomarkers
