摘要
目的探讨2型糖尿病(T2DM)患者血清胱抑素C(CysC)测定对诊断糖尿病早期肾损害的价值。方法根据受检者尿清蛋白排泄率(UAER)水平将100例T2DM患者分为3组,即正常组、微量组、大量组,对100例糖尿病患者和40例健康对照者的血清同时进行了CysC、尿素(Urea)、肌酐(Crea)3个项目的检测,并作对比分析。结果微量清蛋白组和大量清蛋白组的CysC均高于健康对照组,差异具有统计学意义(P<0.05);正常组与健康对照组比较各项检测结果相近,差异无统计学意义(P>0.05);大量组的阳性检出率为100%,微量组阳性检出率CysC(97.5%)>Crea(37.5%)>Urea(20.0%)。结论 CysC检测可作为发现糖尿病早期肾损害敏感而又可靠的常规指标。
Objective To explore the clinical diagnostic value of the determination of serum cystatin C in type 2 diabetic mellitus（T2DM）patients with early renal injury.Methods According to the urinary albumin excretion rate（UAER）,100 cases of type 2 diabetes were divided into three groups,including normal,micro amount and large amount groups.Serum CysC,Urea and Crea were parallelly detected and performed the comparative analysis in 100 cases of observation group and 40 cases of healthy control group.Results Compared with the healthy control group,the serum CysC,in micro and large amount groups were significantly increased（P0.05）,but the difference between normal group and healthy control group had no statistical significance（P0.05）.The positive rate in large amount group was 100%.The positive rates in micro amount group were CysC（97.5%） Crea（37.5%） Urea（20.0%）.Conclusion CysC may be used as sensitive and reliable index of diagnosing early renal injury in type 2 diabetic mellitus.
出处
《检验医学与临床》
CAS
2013年第1期52-53,共2页
Laboratory Medicine and Clinic
关键词
血清胱抑素C
糖尿病
肾损害
cystatin C
diabetes mellitus
renal injury
