摘要
目的了解军队师以上干部感染病原菌分布及药物敏感性情况,指导临床合理选择抗菌药物。方法分离细菌经鉴定后,采用微量肉汤稀释法进行药敏试验,采用SPSS 17.0软件进行统计分析,按临床实验室标准化协会(CLSI)判断药物敏感率。结果 420株病原菌经鉴定有59种,其中革兰阴性菌358株,占85.24%;分离率前10位的菌株有315株(占75.00%),以大肠埃希菌和铜绿假单胞菌为首;分离前5位的细菌中肺炎克雷伯菌对抗菌药物的敏感率较高,而大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌和鲍氏不动杆菌仅对少数几种抗菌药物敏感,对多种抗菌药物的敏感率<60%。结论军队师以上干部感染病原菌以革兰阴性菌为主,对病原菌敏感的抗菌药物种类少且常呈多药耐药,及时掌握该就医群体常见病原菌及药敏情况可为感染治疗提供有力的依据,有助于临床合理选用抗菌药物。
Objective To investigate the pathogen distribution and antimicrobial resistance of clinical isolates from infections of cadres above division-level of PLA. Methods Clinical isolates were collected and identified.The drug susceptibility testing of antimicrobial agents was carried out through broth microdilution method.The susceptivity was read according to standards of CLSI.SPSS 17.0 software was used to analyze the data. Results The 420 clinical isolates fell into 59 species and 358（85.24%） of the isolates were Gram-negative.The top ten pathogens in isolate numbers had a total of 315（75.00%） isolates.The top two pathogens were Escherichia colic and Pseudomonas aeruginosa.Among the top five pathogens,Klebsiella pneumoniae showed relatively high susceptibility to antimicrobial agents.Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus,and Acinetobacter baumannii were only susceptible to a few antimicrobial agents,and their overall susceptibility rate was 60%. Conclusion The common pathogens of infections from cadres above division-level of PLA are Gram-negative bacilli.The strains isolated are multiple drug-resistant and showed high susceptibility to only a few antimicrobial agents.Studying the features and antimicrobial resistance of the pathogens can provide powerful evidence to guide treatment for infections,especially in the selection of medications.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第1期95-97,共3页
Chinese General Practice
