摘要
目的了解老年患者肺部感染的病原菌分布及药物敏感性情况,指导临床合理选择抗菌药物。方法分离细菌经VITEK-2鉴定后,采用K-B法进行药物敏感试验,WHONET5.0软件进行统计分析,按CLSI 2008年标准判断药物敏感率。结果 10 970株病原菌经鉴定有62种,分离率前10位的菌株有10 305株(93.94%),其中90.0%为革兰阴性菌,以铜绿假单胞菌为首;分离前5位的细菌中肺炎克雷伯菌对抗菌药物的敏感率较高,而金黄色葡萄球菌除对万古霉素、替考拉宁和利奈唑胺的敏感率为100.00%外,对其他药物的敏感率<30.00%;铜绿假单胞菌、鲍氏不动杆菌对多种抗菌药物的敏感率<60.00%。结论老年患者肺部感染病原菌以革兰阴性菌为主,对抗菌药物表现出不同程度的耐药,临床应结合药敏试验结果进行选药。
OBJECTIVE To investigate the distribution and antimicrobial resistance of clinical isolates from old patients suffered from pulmonary infection. METHODS Clinical isolates were collected and identified by VITEK Ⅱ. The susceptibility testing of antimicrobial agents was determined by K-B disk method. The susceptibity were read according to standards of CLSI（2008）. WHONET5. 0 software was used to analyze the data. RESULTS There were 62 species from total 10 970 clinical isolates. 90% isolates were Gram-negative bacilli, and the Pseudomonas aeruginosa was the top one. The antimicrobial agents against Klebsiella spp showed relatively high susceptibility, but the susceptible rate of Staphylococcus aureus to antimicrobial agents was less than 30% except vancomycin, teicoplanin and linezolid （all 100%）. The susceptible rates of P. aeruginosa and Acinetobacter baumannii were less than 60.00%. CONCLUSION The common pathogens of pulmonary infection from old patients are Gram-negative bacilli. The resistant rates of these pathogens are increasing, and clinics should select antimicrobial agents based on the susceptibility testing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第4期810-811,共2页
Chinese Journal of Nosocomiology
关键词
肺部感染
病原菌
抗菌药物
敏感性
Pulmonary infection Pathogen Antibiotic Susceptibility
