摘要
目的探讨乌司他丁对老年患者不同麻醉方式术后认知功能障碍的影响以及血清细胞因子差异。方法将60例接受腹腔镜胆囊切除术患者随机分成乌司他丁+全凭静脉麻醉组(I组),乌司他丁+全凭吸入麻醉组(II组),分别在术前1d拔管后1h、24h、4d、7d进行简易智力状态检查评分。结果两组患者简易智力状态检查评分均有不同程度的下降,拔管后1h最明显,与术前相比无统计学意义(P>0.05);I组与II组在所有时点两两比较,差异无统计学意义(P>0.05)。两组患者血清稳态氧化氮产物在所有时点两两比较,差异无统计学意义(P>0.05)。结论乌司他丁可降低老年患者术后POCD的发生率,并减轻其发病程度。
Objective To determine tile value of ulinastatin used to decrease the rate of postoperative cognitive dysfunc Lion （POCD）. Methods Sixty ASA 1 or H patients with hip replacement were divided into three groups：group 1 received ulinasta- tin 20u mixed with NS50 ml and tile patients received ＇FII~.A; group 11 received ulinastatin 20u mixed with NS50 ud and tile pa- tients received TIVA. The mini-metal state exanunation （MMSE）was used to assess tile cognitive function before and lh,24h ,4d, 7d ＇after operation. Results. The MMSE of the patients in two groups were found declined. And the most severity of PoCD was found at the first hour after extubation. The MMSE in group / and group 11 was the same as before the operation （ P 〉 0. 05 ）. The plasma concentrations of stable NO products（ nltrate/nitrite, NOx）were performed same in two groups（ P 〉 0. 05 ）. Conclusion Ulinastatin could decrease the rate of POCD and lighten the degree after the operation.
出处
《四川医学》
CAS
2012年第12期2092-2094,共3页
Sichuan Medical Journal
关键词
乌司他丁
老年患者
简易智力状态检查
血清稳态氮产物
术后认知功能障碍
Ulinastatin
elderly patient
mini-metal state examination
stable nitric oxide prouets
postoperative cog,fi- tire dysfunction
