摘要
目的探讨国产加贝酯预防ERCP术后胰腺炎、高淀粉酶血症和腹痛的疗效和安全性。方法按随机双盲法将拟行ERCP术的患者分为加贝酯组和对照组。加贝酯组患者在ERCP术前30～90min起开始静脉滴注加贝酯至术后12h为止，总剂量为1000mg。对照组仅静脉常规补液。结果共有77例患者完成研究，其中加贝酯组39例，对照组38例。加贝酯组有2例（5％）、对照组有8例（21％）患者发生了胰腺炎（P=0．038）；高淀粉酶血症的发生率两组分别为9例（23％）和18例（47％）（P=0．013）；腹痛的发生率两组分别为9例（23％）和13例（34％）（P=0．280）。结论加贝酯持续静脉滴注能有效减少ERCP术后胰腺炎发生率，减少高淀粉酶血症的发生。
Objective To examine the prophylactic effect of Gabexate on post-ERCP pancreatitis, hyperamylasemia and abdominal pain. Methods Patients scheduled for ERCP were randomized to two groups： patients in Gabexate group were treated with continuous intravenous infusion of 1000 mg Gabexate dissolved in 1750 ml solution,starting 30-90 min before the endoscopic maneuvers and continuing for 12 h after ERCP; patients in placebo group were treated only with the solution for 12 h. Results A total of 77 patients enrolled in the final analysis. Post-ERCP pancreatitis occurred in 2 patients （5%）of Gabexate group and 8 patients （21%） of placebo group （ P = 0. 038 ） ; hyperamylasemia occurred in 9 patients （ 23% ） of Gabexate group and 18 patients （47%） of placebo group （P = 0. 013 ） ;and pancreatic pain occurred in 9 patients （23%） of Gabexate group and 13 patients （34%） of placebo group （P =0. 280）. Conclusion The results suggest that 12 h infusion of gabexate with a total dosage of 1000 mg seems to prevent post-ERCP pancreatitis ,hyperamylasemia effectively.
出处
《中华消化内镜杂志》
2007年第2期100-102,共3页
Chinese Journal of Digestive Endoscopy
关键词
胰胆管造影术
内窥镜逆行
胰腺炎
加贝酯
术后
Cholangiopancreatography, endoscopic retrograde
Pancreatitis
Gabexate
