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对乙酰氨基酚性肝损伤机制的研究进展 被引量:3

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摘要 对乙酰氨基酚(Acetaminophen,简称AP)在英国被叫做扑热息痛,是一个解热镇痛药。对乙酰氨基酚的镇痛作用机制尚未十分明了,可能是通过抑制中枢神经系统中前列腺素(PG)的合成以及阻断痛觉神经末梢的冲动而产生镇痛作用。对乙酰氨基酚本身无毒性,但高剂量的对乙酰氨基酚可使CYP2E1活性增强,从而产生大量的毒性物质(NAPQI、亲电子基、氧自由基)进而引起肝细胞的严重损伤。iNOS抑制剂和N-乙酰半胱氨酸等影响CYP450活性的药物或物质可显著降低对乙酰氨基酚对肝的毒性。
出处 《新疆畜牧业》 2012年第12期22-25,共4页
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参考文献31

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