摘要
目的探讨血清氧化低密度脂蛋白(ox-LDL)/β2-糖蛋白Ⅰ(β2-GPI)复合物水平与2型糖尿病(T2DM)合并冠心病(CHD)的关系及其临床意义。方法选取T2DM合并CHD患者68例、单纯T2DM患者69例、单纯CHD患者65例、门诊健康体检者60名。用酶联免疫吸附试验(ELISA)检测血清ox-LDL/β2-GPI复合物水平,并测定空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1C)和空腹血清胰岛素(FINS)、计算体重指数(BMI)及腰臀比(WHR),并作相关分析。结果 T2DM合并CHD组血清ox-LDL/β2-GPI复合物水平均显著高于单纯T2DM组、单纯CHD组和对照组,差异有统计学意义(P<0.05);T2DM合并CHD组ox-LDL/β2-GPI复合物水平均与TG和HOMA-IR呈正相关(r=0.219、0.228,P均<0.01);TG和ox-LDL/β2-GPI复合物是T2DM危险因素,ox-LDL/β2-GPI复合物和HbA1C是T2DM合并CHD的危险因素。结论血清ox-LDL/β2-GPI复合物与T2DM合并CHD的发病有一定联系。
Objective To investigate the roles of serum oxidized low density lipoprotein（ox-LDL）/beta2-glycoprotein Ⅰ（β2-GPI） complex in type 2 diabetes mellitus（T2DM）patients complicated with coronary heart disease（CHD）and its clinical significance.Methods Serum samples were collected from 68 T2DM patients complicated with CHD,69 patients with T2DM,65 patients with CHD and 60 healthy controls.Serum ox-LDL/β2-GPI complex were measured by enzyme-linked immunosorbent assay（ELISA）,and the fasting blood glucose（FBG）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,glycosylated hemoglobin（HbA1C）,fasting serum insulin（FINS）,body mass index（BMI）and waist to hip ratio（WHR）were determined and analyzed.Results The T2DM patients complicated with CHD had significantly higher levels of ox-LDL/β2-GPI complex than T2DM group,CHD group and control group（P0.05）.The ox-LDL/β2-GPI complex level was positively correlated with TG and homeostasis model assessment insulin resistance（HOMA-IR） index in the T2DM patients complicated with CHD（r =0.219 and 0.228,P0.01）.TG and ox-LDL/β2-GPI complex were the risk factors of T2DM.The ox-LDL/β2-GPI complex and HbA1Cwere the risk factors of T2DM complicated with CHD.Conclusions Serum ox-LDL/β2-GPI complex may play an important role in the development of T2DM complicated with CHD.
出处
《检验医学》
CAS
2012年第11期944-947,共4页
Laboratory Medicine
关键词
低密度脂蛋白
β2-糖蛋白Ⅰ
2型糖尿病
冠状动脉心脏病
Low density lipoprotein
Beta2-glycoprotein Ⅰ
Type 2 diabetes mellitus
Coronary heart disease
