摘要
目的探讨18F-脱氧葡萄糖(FDG)PET/CT显像在子宫颈癌治疗后监测有无肿瘤复发及转移灶中的临床应用价值。方法 子宫颈癌治疗后患者48例,行全身18F-FDG PET/CT检查,肿瘤复发和(或)转移病灶根据病理结果、多种影像学诊断及临床随访而确诊。随访时间>1年。采用SPSS 11.5软件进行统计学处理。结果 48例患者共行54次PET/CT显像,真阳性26例次,真阴性24例次,假阴性1例次,假阳性3例次。18F-FDG PET/CT显像诊断子宫颈癌治疗后肿瘤复发和(或)转移病灶的敏感度、特异性、准确性、阳性预测值及阴性预测值分别为96.3%(26/27)、88.9%(24/27)、92.6%(50/54)、89.7%(26/29)、96.0%(24/25)。检查后部分患者的诊断和治疗方案发生了改变,有24例(50.0%)患者改变了诊断,其中21例(43.8%)改变了治疗方案。结论 PET/CT显像可以较准确地早期探查子宫颈癌治疗后的复发病灶和转移灶,包括盆腔外的远处转移,明确再分期,有助于临床医生确定正确的治疗方案。尽管有其一定的局限性,PET/CT显像仍可作为子宫颈癌治疗后监测的常规检查手段。
Objective To evaluate the contribution of ^18SF-FDG PET/CT to detect local recurrence and distant metastasis of cervical cancer after treatment. Methods Forty-eight female patients received PET/CT imaging after treatment for cervical cancer proved by histopathology. The final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up over 1 year. Results A total of 54 surveillance scans were performed in 48 patients. There were 26 true-positive scans, 24 true-negative, 1 falsenegative and 3 false-positive. The sensitivity, specificity, accuracy, positive predictive, and negative predictive value of PET/CT for the detection of local recurrence and distant metastasis were 96.3 % （ 26/27 ） ,88.9 % （ 24/27 ） ,92.6% （ 50/54 ） ,89.7 % （ 26/29 ） ,96.0% （24/25） ,respectively. The subsequent diagnosis of 24 patients was modified and the subsequent treatment plan of 21 patients was altered. Conclusions ^18F-FDG PET/CT imaging has high accuracy in detection of recurrence and metastatic lesions of cetvieal cancer after treatment including early extra-pelvic metastasis. Re-staging definitely will contribute to confirm treatment plan by clinician. In spite of its limitations, it could be a conventional imaging method for cervical cancer after treatment.
出处
《实用肿瘤杂志》
CAS
2013年第1期75-78,共4页
Journal of Practical Oncology
