摘要
目的探讨血清胱抑素C(CysC)、β2-微球蛋白(β2-MG)、清蛋白(ALB)、尿素(BUN)、肌酐(CRE)及尿α1-微球蛋白(α1-MG)、转铁蛋白(TRF)、免疫球蛋白(IgG)、微量清蛋白(MA)等检测肾功能损害指标的敏感度及对2型糖尿病患者肾脏早期损害的诊断价值。方法用全自动生化分析仪、特种蛋白分析仪等仪器对96例2型糖尿病患者的上述指标进行检测,并对结果用统计学方法进行分析比较。结果 2型糖尿病患者的上述各指标有不同程度的变化,其敏感性由高到低依次为血清CysC、β2-MG、尿α1-MG、TRF、IgG、MA、血清ALB、CRE、BUN。结论 2型糖尿病患者肾脏存在着不同程度的损害,各项指标对肾脏早期损害有着较好的诊断作用,经过对测试结果的对比分析显示:(1)除BUN、CRE外各项指标均能较敏感地反映肾脏早期损害。(2)敏感的程度(由高到低)分别为血清CysC、β2-MG、尿α1-MG、TRF、IgG、MA、血清ALB、CRE、BUN。(3)综合各因素,CysC是肾脏早期损害的最佳诊断指标,传统的BUN、CRE不能作为肾脏早期损害的有用诊断指标。
Objective To explore the sensitivity of the index and the diagnostic value of serum CysC,β2-MG,ALB,BUN,CRE and urine α1-MG,TRF,IgG,MA in early diabetic nephropathy.Methods Testing the above indexes for 96 cases of type 2 diabetes by automatic biochemistry analyzer,special protein analyzer and so on,and comparing the results with statistical methods.Results The above indexes of type 2 diabetes have different change,the sensitivity from high to low in turn is serum CysC,β2-MG,urine α1-MG,TRF,IgG,MA and serum ALB,CRE,BUN.Conclusion There are different degree of kidney damage in type 2 diabetes,and all the indexes have good diagnostic value to the kidney early damage,through the comparison of the testing results show：（1）All the indexes can sensitively reflect kidney early damage except BUN,CRE.（2）The sensitive degree（from high to low）is serum CysC,β2-MG,urine α1-MG,TRF,IgG,MA and serum ALB,CRE,BUN.（3）Comprehensive factors,CysC is the best diagnosis index of kidney early damage,and the traditional BUN,CRE can not be used as the useful index of early diagnosis of renal damage.
出处
《检验医学与临床》
CAS
2013年第2期161-162,164,共3页
Laboratory Medicine and Clinic
