摘要
目的评价容积二氧化碳图（VCap）及其指标诊断慢性阻塞性肺疾病（COPD）患者换气功能障碍的临床应用价值。方法比较分析COPD组92例与对照组48例VCap及其11项指标[Bohr测定法死腔（VD-B）、呼气末最大CO2浓度（CO2 max）、呼出气CO2浓度为25％～50％时的容量（Vm25-50）、呼出气CO2浓度为50％～75％时的容量（Vm50-75）、潮气量（VT）、VD—B／VT、Vm25-50／VT、Vm50-75／VT、Ⅱ期斜率（dC／dV2）、Ⅲ期斜率（dC/dV3）和Ⅲ期斜率/Ⅱ期斜率×100（SR23）]的差别。结果COPD组与对照组C02max、Vm50-75、VT、VD—B／VT、Vm25-50/VT、Vm50-75/VT、dC／dV2、dC／dV3和SR23等9项指标差异有统计学意义（P〈0．05）。在COPD组中，Ⅱ级与Ⅲ级的VD-B/VT、Vm25-50/VT、dC／dV3和SR23等4项指标差异有统计学意义（P〈0．05）；II级与Ⅳ级的dC/dV2、dC／dV3和SR23等3项指标差异有统计学意义（P〈0．05）；III级与Ⅳ级dC/dV3和SR23等2项指标差异有统计学意义（P〈0．05）。结论COPD组VCap曲线形态有异常改变，dC/dV3和SR23可作为最佳诊断指标。VCap检测技术具有无创性和价廉等优点．是诊断COPD换气功能状况的好方法。
Objective To evaluate on volumetric capnography （VCap） change of patients with chronic obstructive pulmonary diseases（COPD）, diagnosing their dysfunction of ventilation. Methods Compard the differences between the 92 patients of COPD group and 48 healthly people of control group on VCap and its indices （ VD-B, CO2max, Vm25-50 , Vm50-75 , VT, VD-B/VT, Vm25-50/VT, Vm50-75/VT, dC/dV2 ,dC/dV3 and SR23）. Results There were significant differences （ P 〈 0.05 ） between COPD group and control group on VCap and its indices （CO2 max, Vm50-75 , VT, VD-B/VT, Vm25-50/VT, Vm50-75 / VT,dC/dV2 ,dC/dV3 and SR23）, between COPD II and COPD III on VCap indices （VD-B/VT, Vm25-50 / VT,dC/dV3 and SR23）, between COPDII and COPDIV on VCap indices （dC/dV2 ,dC/dV3 and SR23）, between COPD III and COPDIV on dC/dV3 and SR23. Conclusions The shape of VCap curve of the COPD group were significant different from the control group. For diagnosing dysfunction of ventilation COPD patient, the dC/dV3 and SR23 were the best indices, and the VD B/VT,Vm25-50/VT and Vm50-75/VT were more significant than the VD-B,CO2 max,Vm25-50 and Vm25-75.
出处
《国际呼吸杂志》
2011年第13期980-983,共4页
International Journal of Respiration
关键词
慢性阻塞性肺疾病
容积二氧化碳图
肺换气功能
Chronic obstructive pulmonary disease
Volumetric capnography
Pulmonary gas exchange function
