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Cofilin在肿瘤中作用的研究进展 被引量：4

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摘要 丝切蛋白（Cofilin）是一种低分子量（21KD）的肌动蛋白结合蛋白，普遍存在于真核生物中。Cofilin的活性受多种因素的调节而发挥着不同的作用，近年来关于cofilin在恶性肿瘤中的表达作用受到了很大的关注，肿瘤细胞中Cofilin表达异常，与肌动蛋白形成复合物改变细胞的正常功能。
作者 孟令杰 邢风娟 王岩
机构地区 吉林大学中日联谊医院临床基因诊疗中心
出处 《中国实验诊断学》 2013年第1期177-178,共2页 Chinese Journal of Laboratory Diagnosis
基金 国家自然科学基金(项目编号:81172000)
关键词 COFILIN 恶性肿瘤 COFILIN 结合蛋白 肌动蛋白 肿瘤细胞 低分子量 真核生物
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献13

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二级参考文献35

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共引文献21

同被引文献36

  • 1蔡碧涓,赵继懋,顾方六.恶性肿瘤侵袭及转移机制的研究进展[J].中华泌尿外科杂志,1995,16(1):50-53. 被引量：3
  • 2Wang Y, Kuramitsu Y, Ueno T, et al. Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues[J].Oncol Rep, 2011, 26(6): 1595-9.
  • 3Lee EK, Cho H, Kim CW. Proteomic analysis of cancer stem cells in human prostate cancer cells[J]. Biochem Biophys Res Commun, 2011, 412(2): 279-85.
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  • 6Becker M, De Bastiani MA, Muller CB, et al. High cofilin-1 levels correlate with cisplatin resistance in lung adenocarcinomas [J]. Tumour Biol, 2013 Sep 10. [Epub ahead of print].
  • 7Bamburg JR. Proteins of the ADF/cofilin family: essential regulators of actin dynamics[J]. Annu Rev Cell Dev Biol, 1999, 15: 185-230.
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  • 10Jang I, Jeon BT, Jeong EA, et al. Pakl/LIMK1/eofilin pathway contributes to tumor migration and invasion in human Non-Small cell lung carcinomas and cell lines[J]. Korean J Physiol Pharmacol, 2012, 16(3): 159-65.

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二级引证文献11

中国实验诊断学
2013年 第1期

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