摘要
目的:采用不同孔径钛铝金属间化合物多孔材料(TAICPM)分离大黄虫丸,探讨经不同孔径TAICPM处理后的大黄虫丸抗动脉血栓形成的作用及机制。方法:选择70只SD雄性大鼠随机分为7组,其中正常组、模型组、对照组各10只,TAICPM组40只:1-5μm组、5-10μm组、10-15μm组、15-20μm组,每组各10只。血栓干重、血小板计数、血栓素B2(TXB-2)和6酮前列腺素F1α(6-keto-PGF1α)作为观察指标,评价经TAICPM分离后大黄虫丸抗动脉血栓形成的效果。结果:①对照组及TAICPM组血栓干重、血小板计数明显少于模型组(P<0.05),TXB-2和6-keto-PGF1α也较模型组有显著性差异(P<0.05);②TAICPM组血小板计数明显低于对照组(P<0.01),TXB-2和6-keto-PGF1α也较对照组有统计学差异(P<0.01);③1-5μm多孔材料组血栓干重明显低于其它3个多孔材料组(P<0.01),血小板计数、TXB-2和6-keto-PGF1α也较其它3组有显著性差异(P<0.01)。结论:经TAICPM处理后的大黄虫丸在抑制动脉血栓形成方面优于未处理的大黄虫丸,其中孔径为1-5μm的多孔材料效果更优。
Objective： To select the main anti-arterial thrombosis herbs of Dahuang Zhechong Pill by different pore size Ti-AI intermetallic compound porous material, and discuss the mechanism of Dahuang Zhechong Pill with Ti-A1 intermetailic compound porous material on anti-arterial thrombosis. Methods： 70 SD male rats were randomly divided into 7 groups, normal group 10 rats, model group 10 rats, control groups 10 rats, Ti-Al intermetailic compound porous material group of 40 rats（which were divided into four groups evenly, first group with 1μm-5μm pero size material, second group with 5μm-10μm, third group with 10μm-15μm, fourth group with 15μm-20μm）. Inducing the left carotid artery thrombosis model with the method of using ferric chloride, observed the indicators of thrombus weight, platelet count, TXB-2 and 6-keto-PGF1α, and selected the best combination of Dahuang Zhechong Pills on anti-arterial thrombosis. Results： （~）Control groups and Ti-A1 intermetallic compound porous material groups had better anti-thrombotic effect and could significantly reduce thrombus dry weight and platelet count（P〈0.05） and adjust vasoactive substances biochemical level better （TXB-2 and 6-keto-PGF1 α, P〈0.05）, compared with model group. （1）Ti-A1 intermetallic compound porous material groups had the better effect on anti-thrombotic and could significantly reduce thrombus dry weight and platelet count（P〈0.01） and adjust vasoactive substances biochemical level （TXB- 2 and 6-keto-PGF1α, P〈0.01）, compared with control group. （3）ljxrn-5μm groups could significantly reduce thrombus dry weight and platelet count（P〈0.01） and adjust vasoactive substances biochemical level （TXB-2 and 6-keto-PGF1 α P〈0.01）, compared
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第2期343-346,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
科技部国际合作项目(No.2010FA32370)
湖南省科技厅国际合作重点项目(No.2008WK3002)
中国博士后科学基金(No.20060390891)~~
关键词
大黄虫丸
动脉血栓形成
钛铝金属间化合物多孔材料
Dahuang Zhechong Pill
Arterial thrombosis
Ti-Al intermetallic compound porous material
