摘要
目的观察归芪通乳合剂对缺乳大鼠模型血清催乳素(PRL)、雌二醇(E2)、多巴胺(DA)水平的影响,探讨其催乳机制。方法建立溴隐亭诱导的大鼠缺乳模型,采用酶联免疫法检测归芪通乳合剂对缺乳大鼠血清PRL、E2、DA水平的影响。结果与溴隐亭缺乳大鼠模型组比较,归芪通乳合剂各剂量组能显著提高溴隐亭缺乳大鼠血清PRL、E2含量(P<0.05),降低DA的水平(P<0.05)。结论归芪通乳合剂催乳机制与提高PRL、E2含量及降低DA的水平有关。
Objective To observe the effect of Guiqi Tongru Mixture on serum prolactin, estradiol and dopamine in rats with postnatal lack of lactation. Methods Rat model of postnatal lack of lactation was induced by bromocriptine. The expression of serum prolactin, estradiol and dopamine in the model rat was detected by enzyme-linked immunosorbent assay. Results Compared with the model group, the serum prolactin and estradiol contents of Guiqi Tongru Mixture groups were increased significantly（both P 〈 0.05）,while the dopamine expression level was decreased significantly（P 〈 of prolactin and 0.05）. Conclusion The lactagogue mechanism of Guiqi Tongru Mixture may be related to its increase estradiol contents and to its inhibition of dopamine expression
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第1期36-38,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
重庆市科技计划项目(2010GGD057)
关键词
归芪通乳合剂
缺乳大鼠模型
产后缺乳
Guiqi Tongru Mixture
Lack of lactation rat model
Postnatal lack of lactation
