摘要
目的通过测定急性冠状动脉综合征患者血浆N-端脑利钠肽前体(NT-proBNP)水平并分析其与冠状动脉病变严重程度的相关性。方法回顾性分析行冠状动脉造影检查并结合病史诊断为急性冠状动脉综合征的患者40例,另选20例冠状动脉造影检查阴性者为对照组。冠状动脉病变严重程度使用Gensini评分。急性冠状动脉综合征患者根据Gensini积分被分为Gensini积分≥30分组和<30分组,按冠状动脉病变支数分为单只、双支和三支病变组。采用免疫定量分析仪及配套试剂测定所有患者血浆NT-proBNP水平,分析NT-proBNP与冠状动脉病变严重程度的相关性。结果急性冠状动脉综合征组NT-proBNP水平明显高于对照组[242.56±68.16 ng/L比27.12±16.48 ng/L,P<0.01]。血浆NT-proBNP水平三支病变组高于单支病变组(P<0.05)。Gensini积分≥30分组NT-proBNP水平明显高于Gensini积分<30分组[228.14±46.16 ng/L比127.64±32.64 ng/L,P<0.05]。血浆NT-proBNP水平与Gensini积分呈正相关(r=0.56,P<0.05)。结论急性冠状动脉综合征患者血浆NT-proBNP水平在评价冠状动脉病变严重程度方面具有一定的临床意义。
Aim To analyze correlation between the N-terminal brain natriuretic peptide precursor （NT-proBNP） levels and severity of coronary artery disease in patients with acute coronary syndrome （ACS）. Methods 40 patients was diagnosed with ACS combined coronary angiography and history, replacement of the 20 cases in the control group was coronary angiography negative. Gensini score was used for the evaluation of coronary lesions severity. According to Gensini score, ACS patients were divided into the Gensini score ≥30 group and 〈 30 group. And according to the number of diseased vessels, ACS patients were divided into single, double and three vessels disease groups. Immunoassay analyzer and ancillary reagents were used for detemlination of plasma NT-proBNP level in all patients. The correlation between NT-proBNP levels and the severity of coronary artery disease was analyzed. Results NT-proBNP levels of ACS group were significantly higher than that in the control group [ 242. 56 ± 68. 16 ng/L vs 27. 12 ±16. 48 ng/L, P 〈 0. 01 ]. The level of NT-proBNP in three-vessel disease group was higher than in single-vessel disease group （P 〈0. 05）. In Gensini score≥30 group, NT-proBNP level was signifi- cantly higher than that in Gensini score 〈 30 group [ 228. 14 ±46. 16 ng/L vs 127. 64 ±32. 64 ng/L,P 〈 0. 05 ]. Plasma NT- proBNP level was positively correlated with the Gensini score （r = 0. 56, P 〈 O. 05）. Conclusions Plasma NT-proBNP levels in patients with ACS has clinical significance in the evaluation of coronary artery disease severity.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2013年第2期162-164,共3页
Chinese Journal of Arteriosclerosis
基金
中国人民解放军第九七医院课题基金(YN2011019
YN2011020)
关键词
急性冠状动脉综合征
N-端脑利钠肽前体
冠状动脉病变
Acute Coronary Syndrome
N-Terminal Brain Natriuretic Peptide Precursor
Coronary Artery Disease
