摘要
肝缺血再灌注(IR)损伤是引起肝脏损害的重要因素,已成为研究的热点和难点。近年来研究发现HSP70在组织、器官的IR损伤中起了重要的保护作用,笔者就其在肝IR损伤中的作用作一综述,并重点阐述其作用机制,如调控炎症因子、抗细胞凋亡以及抗氧化作用等。
Hepatic ischemia-reperfusion （IR） injury is a major cause of liver damage, and has become a hot and difficult field of study. Recent investigations reveal that heat shock protein 70 （HSP70） plays a critical role in protection of tissues and organs against IR injury. This paper overviews the actions of HSP70 in liver IR injury, which puts a special emphasis on the mechanisms underlying its protective effect such as regulation of inflammation factors, and anti-apoptotic and antioxidative effect.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2013年第1期98-103,共6页
China Journal of General Surgery
基金
江苏省扬州市社会发展科技攻关项目基金资助项目(YZ2010087)
