摘要
目的:探讨Twist和Snail蛋白在乳腺癌组织中的表达及其与微血管密度的关系。方法:应用免疫组织化学法检测80例乳腺癌组织Twist、Snail蛋白的表达情况。CD34抗体标记乳腺癌血管内皮细胞,计算微血管密度(MVD)。结果:乳腺癌组织中Twist的阳性表达率为67.5%(54/80),Snail的阳性表达率为72.5%(58/80),Twist、Snail阳性组MVD显著高于Twist、Snail阴性组,P<0.05。在乳腺癌组织中Twist、Snail蛋白的表达之间存在显著正相关,r=0.529,P<0.01。结论:乳腺癌组织中存在Twist、Snail蛋白的高表达,两者的联合表达能增加肿瘤细胞侵袭力,促进乳腺癌的浸润、转移,联合检测有助于判断患者的预后。
Objective：To study the expression of Twist and Snail in breast cancer and their relationship with angiogenesis. Methods： Expression of Twist and Snail was detected in 80 cases of breast cancer tissue by immunohistochemistry. CD34 marking vascular endothelial eel1 was used to measure the microvascular desity （MVD）. Results：The positive Twist expression was 67.5% in breast cancer,and the positive Snail was 72.5%. The positive group of Twist and Snail protein had higher MVD than that in negative group（ P 〈 0.05 ）. There was a significant correlation between the expressions of Twist and Snail in breast cancer, r = O. 529 ,P 〈 0.01. Conclusion：The overexpression of Twist and Snail protein were found in breast cancer. Their co - expression could contribute to the invasion and metastasis in human breast cancer. They were valuable molecular markers to be used for monitoring the disease.
出处
《现代肿瘤医学》
CAS
2013年第2期298-301,共4页
Journal of Modern Oncology
基金
扬州大学临床医学院科研课题(编号:yzucms201217)
