摘要
目的:探讨NEDD9在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及意义。方法:应用免疫组化方法检测NEDD9在145例非小细胞肺癌及癌旁正常肺组织中的表达,并分析其表达与肿瘤临床病理因素及预后的相关性。结果:NEDD9在非小细胞肺癌中高表达,在正常肺组织中低表达(P<0.001);在非小细胞肺癌中,NEDD9的高表达与患者的阳性淋巴结转移及高TNM分期正相关(P=0.001和P=0.039);在预后分析中,NEDD9高表达的患者在单因素和多因素分析中均表现出更差的5年累计生存率(P<0.001)。结论:NEDD9促进非小细胞肺癌的侵袭转移,并与较差的预后相关。
Objective：To investigate the expression of NEDD9 protein in non - small cell lung cancer （NSCLC） and paired adjacent normal lung tissue, and assess their correlations with clinicopathological parameters and progno- sis. Methods： The expression level of NEDD9 in NSCLC and normal lung tissue samples was measured by immunohistochemistry. Results ：The expression of NEDD9 in NSCLC was higher than that in normal lung tissue（ P 〈 0. 001 ）. In NSCLC, increased NEDD9 expression was significantly correlated with lymph - node metastasis and TNM Ⅲ a - Ⅲb stage （ P = 0. 0131 and P = 0.039）. In addition, patients with NEDD9 positive expression had poor survival（ P 〈 0. 001 in univariate and multivariate analysis）. Conclusion： NEDD9 may positively regulate invasiveness and metastasis of lung cancer cell, and correlate with progression and poor prognosis in NSCLC.
出处
《现代肿瘤医学》
CAS
2013年第2期282-284,共3页
Journal of Modern Oncology
基金
国家自然科学基金青年基金项目(编号:81000942)
关键词
NEDD9
非小细胞肺癌
淋巴结转移
预后
NEDD9
non- small cell lung cancer
lymph node metastasis
prognosis
