摘要
羊口疮病毒主要感染山羊和绵羊,近年来发现其也可感染包括人在内的多种动物,为一种人兽共患病。对羊口疮病毒的病原学、基因组结构、应用研究、免疫学特性等方面进行了综述,同时对已鉴定的几种病毒重要免疫调节蛋白和毒力基因及其功能进行了详细阐述,较为深入地探究了羊口疮病毒干扰宿主免疫系统及其免疫逃避的分子机制。
Orf also known as contagious ecthyma is caused by orf virus（ORFV）,which mainly affects sheep and goats.In recent years,people and other animals that being affected by ORFV have been reported.The etiology,genome structure,application research and immunological characteristics of ORFV were reviewed,and several acquired immuno-modulatory proteins and pathogenesis-related genes that had been identified were summarized.In addition,the strategies developed for ORFV against the immune system of the host and the molecular mechanism of the immune escape were analyzed.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2013年第1期103-109,共7页
Chinese Veterinary Science
基金
公益性行业(农业)科研专项(201103008)
现代农业产业技术体系建设专项(CARS-40-10)
关键词
羊口疮病毒
基因组学
毒力基因
免疫调节
orf virus
genomics
pathogenesis-related genes
immuno-modulation
