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结直肠癌中SIRT1和Survivin的表达及临床意义 被引量：6

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摘要 目的观察沉默信息调节因子1(silent information reg-ulator 1,Sir1))、凋亡抑制基因Survivin在结直肠癌中的表达,分析SIRT1、Survivin与结直肠癌(colorectal cancer,CRC)患者临床病理学特征的关系以及二者表达间的关系。方法应用免疫组化SP法检测60例结直肠癌组织和24例正常结直肠黏膜中SIRT1、Survivin的表达。结果 SIRT1、Sur-vivin在结直肠癌中的阳性率均高于正常结直肠黏膜(χ2=15.674,P=0.000;χ2=32.747,P=0.000)。SIRT1表达与结直肠癌浸润深度(P=0.021)、淋巴结转移(P=0.020)、pTNM分期(P=0.003)、p53蛋白表达(P=0.024)均呈正相关。Survivin表达与pTNM分期呈正相关(P=0.035)。SIRT1与Survivin表达无明显相关性(P>0.05)。结论SIRT1、Survivin在结直肠癌组织中过表达,且与多项临床病理指标有关,二者可能成为判定CRC恶性程度及评估预后的生物学指标。
作者 马静静 张云良 李志红 朱春英 赵文明 马良燕 郭淑芹
机构地区 承德医学院研究生部 保定市第一中心医院内分泌一科 保定市第一中心医院病理科 承德市承德医学院附属医院
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第1期74-77,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 结直肠肿瘤 SIRT1 SURVIVIN P53 凋亡
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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二级参考文献9

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共引文献7

同被引文献69

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引证文献6

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临床与实验病理学杂志
2013年 第1期

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