摘要
目的观察子宫内膜癌中沉默信息调节因子1(sirtuin type 1,SIRT1)和Survivin的表达及其与临床病理特征的关系。方法应用免疫组化EnVision两步法检测95例子宫内膜癌、40例正常子宫内膜组织中SIRT1和Survivin的表达情况,并结合临床病理特征进行分析。结果子宫内膜癌中SIRT1的阳性率为83.2%,高于正常子宫内膜的阳性率17.5%,差异有统计学意义(χ2=52.480,P<0.001);Survivin的阳性率85.3%高于正常子宫内膜22.5%,差异有统计学意义(χ2=49.897,P<0.001)。SIRT1和Survivin均与临床分期及分化程度有关。结论 SIRT1和Survivin参与子宫内膜癌的形成和增殖,并可能成为判断肿瘤恶性程度及预后的指标。
Purpose To investigate the expression of SIRT1 and Survivin and their association with clinicopathologic features in endo- metrial carcinoma. Methods Immunohistochemistry was carried out to examine the expression of SIRT1 and Survivin in 95 cases of endometrial carcinoma and 40 cases of normal endometrial specimens. The clinicopathological features of patients with endometrial car- cinoma were analysed. Results Expression of SIRT1 and Survivin was significantly increased in endometrial carcinoma tissues com- pared to normal endometrium （ P 〈 0. 05 ）. The expression of SIRT1 and Survivin was closely associated with clinical stage and histolog- ical grade. Conclusions SIRT1 and Survivin may involved in tumorigenesis and proliferation of endometrial carcinoma. SIRT1 and Survivin may be a marker for adjudging the malignant and prognosis of endometrial carcinoma,
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2012年第11期1224-1227,共4页
Chinese Journal of Clinical and Experimental Pathology
