摘要
目的:研究高蛋白饮食对犬体内左氧氟沙星药动学的影响。方法:将6只犬随机均分为空腹组和高蛋白饮食组,高蛋白饮食组犬进食高蛋白饮食每只150g,2组犬分别灌服左氧氟沙星10mg/kg。采用高效液相色谱法检测给药后0.5、1、2、4、8、12、24、48h各组犬体内左氧氟沙星的血药浓度,2周后进行交叉实验,3p97软件计算药动学参数并进行比较。结果:2组犬体内左氧氟沙星的药动学过程均符合二室模型;空腹组和高蛋白饮食组犬体内左氧氟沙星的药动学参数分别为t1/2β:(11.07±8.46)、(21.65±4.65)h,tmax:(3.42±0.41)、(1.53±0.34)h,cmax:(2.71±0.60)、(2.22±0.22)μg/ml,AUC0-48h:(36.51±8.66)、(29.78±4.26)μg·h/ml;除tmax参数组间有显著性差异(P<0.01)外,其余参数均无显著性差异(P>0.05)。结论:高蛋白饮食可使左氧氟沙星tmax减小,促进其吸收。
OBJECTIVE： To study the effects of high protein diet on the pharmacokinetics of levofloxacin in dogs. METH- ODS： 6 dogs were randomly divided into fasting group and high protein diet group; high protein diet group received high protein diet 150 g in each; both groups were given levofloxacin 10 mg/kg. The blood concentration of levofloxacin in dogs was determined by HPLC 0.5, 1, 2, 4, 8, 12, 24 and 48 h after medication, randomly crossed experiments were carried out 2 weeks later; and pharmacokinetic parameters were calculated with 3p97 software. RESULTS： Pharmacokinetics process of Levofloxacin in 2 groups dogs were in accordance with the two compartment model. Main pharmacokinetic parameters of fasting group vs. protein group were as follows： t1/2β ： （11.07 ± 8.46） h vs. （21.65 ± 4.65） h; tmax： （3.42 ± 0.41） h vs. （1.53 ± 0.34） h; Cmax： （2.71 ± 0.60） μg/ml vs. （2.22 ± 0.22） μg/ml; AUC0-48 h： （36.51 ± 8.66） μg· h/ml vs. （29.78 ± 4.26） μg. h/ml, respectively. There was significant difference in tmax （P〈0.01）, while other parameters had no significant difference between 2 groups （P〉0.05）. CONCLUSIONS： High protein diet can reduce t~, promote absorption of levofloxacin.
出处
《中国药房》
CAS
CSCD
2013年第5期410-411,共2页
China Pharmacy
关键词
高蛋白饮食
左氧氟沙星
药动学
犬
High protein diet
Levofloxacin
Pharmacokinetics
Dogs
