摘要
胰岛素样生长因子(IGF)通过其受体和结合蛋白的调节,促进细胞增殖、抑制细胞凋亡。越来越多的研究发现,IGF家族参与包括胃癌在内的许多相关肿瘤发生、发展及预后。近年来对胃癌患者血液中IGF家族进行了大量基础和临床研究的结果显示,IGF家族可能在胃癌的发生、发展及预后中起重要作用。如抑制其受体信号通路可为胃癌的综合治疗提供新靶点;IGF受体的单克隆抗体可作为胃癌的辅助治疗等。现就IGF家族在胃癌领域的最新研究进展进行综述。
Insulin-like growth factors （ IGFs）, regulated by their receptors and binding proteins, play an important role in cell proliferation, differentiation and apoptosis. More and more evidences have showed that IGFs participate in the genesis, progress and prognosis of some related malignancies including gastric cancer. Numerous basic and clinical research results using the blood of patients in recent years show that IGFs play a key role in genesis, progress and prognosis of gastric cancer. For example, the signaling pathways of IGF re- ceptor can be inhibited as a new target to the comprehensive treatment of gastric cancer, its monoclonal anti- body may be used as the adjuvant treatment as well. Here is to make a review on the updates and progress in the research of IGF family in gastric cancer.
出处
《医学综述》
2013年第2期246-249,共4页
Medical Recapitulate
关键词
胃癌
胰岛素样生长因子
基因多态性
靶向治疗
Gastric cancer
Insulin-like growth factor
Gene polymorphism
Targeted therapy
