摘要
应用HPLC分析仪系统研究了多种因素对头孢呋辛钠去离子水溶液稳定性的影响,包括初始浓度、温度、离子强度、pH值及螯合剂EDTA.2Na等。结果显示:头孢呋辛钠去离子水溶液的降解符合一级反应动力学;其稳定性随着温度的升高而降低;在5、15、25、35、39和45℃的保存温度下,其t0.9(有效期)分别为65.1、25.8、15.8、5.6、3.9和2.0 h;得到了头孢呋辛钠水去离子溶液降解反应活化能为62.27 kJ/mol;随着离子强度增大,降解速率加快;在pH值接近7.0的条件下头孢呋辛钠水溶液最为稳定,降解速率在酸性的条件下随pH值变化较慢,在碱性条件下随着pH值增大迅速增大;研究还发现,螯合剂EDTA.2Na虽可减缓溶液颜色变化,但并未减慢其降解速度。以上结果可为优化生产、制剂、存储和应用提供依据。
Via an HPLC,the stability of cefuroxime sodium in deionized aqueous solution was investigated systematically,including factors such as initial concentration,temperature,ionic strength,pH values and EDTA disodium salt solution.The results revealed that the degradation kinetics matched well with the first order reaction.Its stability decreased with the increasing of temperature.The period of validity of cefuroxime sodium was about 65.1,25.8,15.8,5.6,3.9 and 2.0 h with the storage temperature of 5,15,5,35,39,45 ℃ respectively.Its activation energy was about 62.27 kJ/mol.The degradation rate increased with the increasing of ionic strength.As for the effects of the pH values,it revealed that cefuroxime sodium was relatively stable in neutral conditions with a lowest degradation rate.And the degradation rate changed slowly in an acidic condition,but increased rapidly in the alkaline environment.Although the chelating agent（EDTA disodium） could slow down the color change of the cefuroxime sodium deionized aqueous solution,the degradation rate was not decreased.All of the results could provide theoretical basis for the optimizing production,preparation,storage and usage process.
出处
《化学工业与工程》
CAS
2013年第1期8-13,共6页
Chemical Industry and Engineering
基金
天津市自然科学基金(10JCYBJC14200
11JCZDJC20700)
