4Roehar F, Williams GH. Rationale for the use of Aldosterone antagonists in congestive heart failure [ J ]. Drugs, 2002,62 (5) : 723-731.
5Brilla MD, Zannad F, Remme WJ, et al. Tile effect of spironolactone on morbidity and mortality in patients with severe heart failure[ J]. N Engl J Med, 1999,341 (10) :709-717.
6Weber K. Effectiveness of spironolactone added to an angiotensin -converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure [J]. Am J Cardiol, 1996,78(8) :902-907.
7Sharon AH. ACC/AHA guidelines for the evalution and management of Chronic Heart failure in the adult[J]. Am Coll Cardiol,2007,dd(12) :2 101-2 113.
8Duprez EG. Recent studies with eplerenone, a novel selective Aldosterone receptor antagonist[J]. Curr Opin Pharmacol, 2001,1 (2) : 190-196.
9Struthersk AD. Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic hearl failure [J]. J Card Fail, 1996,2( 1 ):47-54.
10Swan KP, Aaronson KD, Koelling TM. Spironolactone-induced renal insufficiency and hyperkalemia in patientswith heart failure [ J ]. American Heart Journal ,2007,148(2) : 971-978.
1Zannad F, Mcmurray JJ, Krum H, et al. Eplerenone in pa- tients with systolic heartfailure and mild symptoms[J]. N Engl J Med,2011,364..ll 21.
2BauerSach J, Heck M, Fraccarollo D, et al. Addition of spi- ronolactone to angiotension-converting enzyme in heart failure improve endothelial vasomotor dysturction~role of vascular su- peroxide anion formation and endothelial nitricoxide synthase expression[J]. JxAM Coil Cardiol,2002,39 ..351-358.
3Richards M, Nichholls G. aLdosterone antagonism in heart failure[J]. The Lancet, 1999 : 1354-1359.
4Pitt B, Pfeffer MA, Assmann SF, et al. Spironolactone for heart failure with preserved ejection fraction[J]. N Engl J Med,2014,370(15) ..1383-1392.
5Edelmann F,Wachter R, Schmidt AG, et al. Effect of spirono lactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction., the Aldo- DHF randomized controlled trial[J]. JAMA, 2013,309 (8) : 781-791.