摘要
目的了解医院近年来铜绿假单胞菌的分布及耐药性变迁的特点,研究铜绿假单胞菌的耐药机制,为临床合理选用抗菌药物提供依据。方法对临床2009-2011年住院患者送检标本所分离的铜绿假单胞菌耐药率进行回顾性统计分析;用K-B纸片扩散法测定其对常用抗菌药物的耐药性。结果共检出阳性标本分离株2675株,其中铜绿假单胞菌有361株,占13.5%;铜绿假单胞菌对临床常用的抗菌药物哌拉西林、头孢曲松、头孢哌酮、氨曲南、亚胺培南的耐药率上升较快,分别由2009年的40.2%、60.8%、55.7%、58.8%、7.2%上升至2011年的55.6%、71.4%、63.5%、68.2%、15.1%;对头孢他啶、环丙沙星、阿米卡星与头孢哌酮/舒巴坦、哌拉西林/他唑巴坦的耐药率尽管也有一定比例上升,但耐药率相对比较稳定且仍然较低。结论临床应加强对产酶菌和多药耐药菌的预防监测;应选择铜绿假单胞菌敏感的抗菌药物治疗,提高抗感染治疗水平。
OBJECTIVE To investigate the distribution and drug resistance of the Pseudornonas aeruginosa isolated in the recent years and study the drug resistance mechanisms so as to provide basis for the reasonable clinical medication. METHODS The drug resistance of P. aeruginosa isolated from the submitted specimens of the hospitalized patients during 2009--2011 was taken for statistical analysis. The resistance to common antibiotics was determined by K-B method. RESULTS Of 2675 strains of clinical isolates, there were 361 （13.5%） strains of P. aeruginosa. The drug resistance rates of P. aeruginosa to piperacillin, ceftriaxone, cefoperazone, aztreonam, and imipenem increased rapidly, which were respectively increased from 40.2%, 60.8%, 55.7%, 58.8%, and 7.2 % to 55.6 %, 71.4 %, 63.5 %, 68.2 %, and 15.1 %. The resistance rates to ceftazidime, ciprofloxacin, amikacin, cefperazone-sulbactam, and piperacillin-tazobactam was also elevated at a certain degree, but the resistance rate remained stable and low. CONCLUSION The hospital should strengthen the monitoring of enzyme-producing bacteria and the multidrug-resistant bacteria. It is necessary to improve the anti-infection treatment with the use of antibiotics sensitive to P. aeruginosa.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第2期449-451,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
病原菌
分布
耐药性
Pseudornonasaeruginosa
Distribution
Pathogen
Drug resistance
