摘要
①目的研究弥漫性脑损伤对大鼠学习记忆功能的损害及奥拉西坦的保护作用。②方法选择雄性Wistar大鼠48只,随机分为正常对照组(12只)、假手术组(12只)、脑损伤组(12只)和药物干预组(12只)。正常对照组不给予任何干预措施;假手术组仅进行头皮切开缝合处理;脑损伤组和药物干预组均制作Marmarou弥漫性脑损伤模型,其中药物干预组在制作模型后定期给予奥拉西坦(200mg/kg/d)。观察14天后,采用Morris水迷宫试验比较各组大鼠搜索安全岛的次数。③结果正常对照组、假手术组、脑损伤组和药物干预组大鼠搜索安全岛的次数分别为(10.1±1.9)次、(10.3±1.8)次、(3.8±2.3)次和(6.3±1.3)次,正常对照组和假手术组大鼠搜索安全岛的次数无统计学差异;脑损伤组和药物干预组大鼠搜索安全岛次数低于前两组大鼠,差异有统计学意义(P<0.05);药物干预组大鼠搜索安全岛次数高于脑损伤组大鼠,差异有统计学意义(P<0.05)。④结论弥漫性脑损伤对大鼠学习记忆能力有一定影响,奥拉西坦可改善大鼠脑损伤后学习记忆的障碍。
Objective To investigate the influence of cognitive ability in rats after diffuse brain injury and the effect of ox-iraeetam. Methods 48 Wister rats were divided randomly into control group（ n = 12） .sham operated group（ n = 12） ,DBI group（ n = 12）and oxiracetam treated group（ n = 12） ,DBI and oxiraeetam treated groups were duplicated by Marmarou method. Oxiraeetam treated group were treated with oxiracetam （200mg/kg/d）in peritoneum after injure, the other groups were treated with saline for comparison at the same time. Morris water mace was taken after 14 days. Results The times of cross safety island after 14 days in control group rats.sham operated group rats,DBI group rats and oxiracetam treated group rats were（ 10.1 ± 1.9）、（ 10.3 ± 1.8）、 （3.8 ± 2.3） and （6.3 ± 1.3 ） responsively. The times of cross safety island in DBI and oxiracetam treated groups were lower than that of control and sham operated groups after 14 days（ P 〈 0. 05 ）, while that of oxiracetam treated group was greater than that of DBI group （ P 〈 0.05 ）. Conclusion DBI may iniluence the cognitive ability of rats ; oxiracetam is effective in recover of cognitive a- bility.
出处
《河北联合大学学报（医学版）》
2013年第1期1-3,共3页
Journal of North China Coal Medical College
