摘要
目的探讨血清白介素18(IL-18)对慢性乙型肝炎(CHB)疾病活动度的影响。方法检测CHB患者血液中ALT、AST、IL-18、乙型肝炎血清学标志物及HBeAg定量、HBVDNA等,并统计分析。结果在CHB患者中,HBeAg阴性组患者血清ALT、AST均较抗HBe阳性组、HBeAg阳性组、正常对照组明显升高(P<0.05),IL-18含量明显升高(P<0.01);HBeAg阴性组患者血清ALT异常率63.6%、IL-18异常率86.4%,二者比较差异有明显统计学意义(P<0.05)。HBeAg阳性组与正常对照组及抗HBe阳性组比较,ALT、AST均明显增高(P<0.05);HBeAg阳性组与HBeAg阴性组比较,HBV DNA拷贝量、HBeAg定量(S/CO值)明显较高(P<0.01,P<0.001);IL-18水平明显较低(P<0.01);HBeAg水平与IL-18水平呈明显负相关关系(r=-0.536、P<0.01),HBeAg阴性组,HBeAg与IL-18水平无明显相关性(r=-0.227、P>0.05)。结论 CHB患者中,HBeAg对机体的免疫应答功能、疾病活动度有明显的影响。IL-18参与了HBV感染后的免疫反应、肝脏损伤过程,且血清IL-18水平与肝损伤程度相关。
Objective To investigate the influence of HBeAg on the function of immune response and state of the illness of the chroic hepatitis B patients. Methods Serum ALT, AST, IL-18, HBV mark, andHBVDNA were measured in the chronic hepatitis B patients,and statistically analyzed. Results Serum ALT andAST of the patients of the HBeAg（ - ） group were significantly higher（P〈0.05）, and so was IL-18 （P〈0.01） ; ALT abnormality rate was 63.6 % and IL- 18 was 86.4 %, and there were significantly differences （P〈 0.05）. In the HBeAg（ ＋ ） group patients, the HBV DNA copies quantity. HBeAg value（S/CO）were significantly higher than in the HBeAg（- ）group patients（P〈0.01, P〈0. 001）, but IL-18 were significantly lower（P〈0.01） ;and there was a significantly negative relationship between the HBeAg and IL-18（r=-0. 227.P〉0.05）. In the HBeAg（-）group patients there was no a significantly relationship between the HBeAg and IL-18（r= -0. 536.P〈0. 01）. Conclusion In the low degree chronic hepatitis B patients, the HBeAg influenced the function of immune response and state of the illness. IL-18 took part in the immunity and regulation and correlated with the pathology. Thus, IL-18is an effectively serology index to evaluate the severity degree of liver inflammation and liver injury.
出处
《成都医学院学报》
CAS
2012年第4期632-634,共3页
Journal of Chengdu Medical College
