摘要
目的对雷贝拉唑钠中的残留溶剂进行测定。方法采用溶液直接进样气相色谱法,DB-5(30m×0.53mm×1.0μm)石英毛细管色谱柱,氢火焰离子化检测器,载气为氮气;进样口温度为150℃,检测器温度为240℃,柱温为60℃。结果被测溶剂均能得到很好的分离,每一个溶剂的峰面积与浓度在一定线性范围内均呈良好的线性关系。结论该方法作为雷贝拉唑钠中残留溶剂的检测准确、可靠。
Objective To establish a method for detection of residual solvents in rabeprazole sodium. Methods The residual solvents in rabeprazole sodium was determined by solution dired-injeetion GC with DB-5 capillary column （30 m x 0.53 mm x 1.0 Ix m） with FID detector and nitrogen as the carries gas.The injector temperature was 150℃ ,the detector temperature was 240℃ ,the column temperature was 40℃ . Results The solvents could be completely separated,and the calibration curves of each solvent had good linear relationship within a certain range, Conclusion The method is proved accurate and reliable,it can be used for the determination of residual solvents in rabeprazole sodium.
出处
《中国医药科学》
2013年第2期106-107,共2页
China Medicine And Pharmacy
