摘要
目的探讨采用黄柏黄芩以及五倍子外用的方法来治疗急性湿疹的治疗效果。方法将药物分为六组,分别为黄柏组、黄芩组、五倍子、黄柏五倍子组、黄芩五倍子组以及阳性药。所有治疗组都与对照组相比较,采用二甲苯诱发的小鼠耳廓肿胀的急性炎症实验、2、4-二硝基氯苯诱发的小鼠迟发型超敏反应实验和体外抑菌试验,考察中药配伍后对药效的影响。结果黄芩五倍子组能够有效减轻二甲苯所导致小鼠的耳廓胀度,用药前与用药后相比较,两者之间的差异具有统计学意义(P<0.01);黄柏五倍子组在降低迟发型超敏反应值上对对照组之间的差异没有统计学意义(P>0.05);在药物浓度降低后,黄芩五倍子组在体外细菌的抑制作用上明显优于黄柏五倍子组。两组之间的差异具有统计学意义(P<0.05)。结论在治疗急性湿疹的时候采用五倍子和黄芩匹配治疗明显比单独使用药物效果更好。
Objective To study and analyze the curative effect of golden cypress, scutetlaria baicalensis and gallnut in the external treatment of acute eczema. Methods The drugs were divided into 6 groups： golden cypress group, scutellaria baicalensis group,gallnut group, golden cypress and gallnut group,scutellaria baicalensis and gallnut group, and positive drug group. All the treatment groups were compared to the control group. The acute inflammation experiment of mouse auricle swelling induced by dimethylbenzene and the delayed hypersensitivity experiment and the in vitro antimicrobial experiment of mice induced by 2,4-dinitrochlorobenzene were used to observe the effect of compatible traditional Chinese medicine. Results In the scutellaria baicalensis and gallnut group, the auricle swelling of mice induced by dimethylbenzene was effectively relieved; The difference in auricle swelling between before medication and after medication was statistically significant（P 〈 0.01）.The golden cypress and gallnut group and the control group were not statistically different in the reduction of delayed hypersensitivity value（P 〈 0.05）.After drug concentration decrease,the scutellaria baicalensis and gallnut group was superior to the golden cypress and gallnut group in the in vitro bacteria inhibition effect, with statistically significant difference between the two groups （P 〈 0.05）. Conclusion In the treatment of acute eczema, the effect of gallnut compatible with scutellaria baicalensis is superior to that of a single drug.
出处
《中国医药科学》
2013年第2期30-31,共2页
China Medicine And Pharmacy
关键词
五倍子
黄芩
黄柏
急性湿疹
Gallnul
Golden cypress
Sculellaria baicalensis
Acute eczema
