摘要
目的:探讨低剂量99mTc-甲氧基异丁基异腈(MIBI)半定量分析在乳腺断层双时相显像诊断乳腺癌中的临床意义。方法:109例乳房肿块患者和26例正常对照者为临床研究对象,使用自制乳腺显像装置进行早期和延迟图像采集,图像行半定量分析(SQA),并与病理检查结果对照。结果:正常对照组、良性病变组、乳腺癌组的早期相T/NT比值分别为1.09±0.18、1.77±1.36、3.98±3.11,3组比较,差异有统计学意义(P<0.05)。正常对照组的早期相与延迟相T/NT比值差异无统计学意义[(1.09±0.18)vs.(1.08±0.19),P>0.05];良性病变组下降,差异有统计学意义[(1.77±1.36)vs.(1.28±0.83),P<0.05];乳腺癌组下降不明显,差异无统计学意义[(3.98±3.11)vs.(3.04±2.46),P>0.05]。半定量分析诊断乳腺癌的灵敏度为97.67%(42/43),特异性为81.82%(54/66),准确性为88.07%(96/109),阳性预测值为77.78%(42/54),阴性预测值为98.18%(54/55)。结论:低剂量99mTc-MIBI乳腺断层双时相显像是诊断乳腺癌的一种行之有效的方法,对鉴别乳腺良恶性病变有很好的临床应用价值。
Objective： This study aims to investigate the clinical significance of the semi-quantitative analysis of low-dose ^99mTc-methoxy isobutyl isonitrile （MIBI） double phase tomographic imaging in breast cancer diagnosis. Methods： A total of 109 patients with breast lesions and 26 normal breasts underwent double-phase ^99mTc-MIBI tomographic imaging using a self-designed imaging device. The early and the delayed tumor to non-tumor ratios （T/NT） were calculated by semi-quantitative image analysis （SQA）. The results were compared with that of the pathological results. Results： The early phase T/NT ratios in the normal control, benign, and breast cancer groups were 1.09±0.18, 1.77±1.36, and 3.98±3.11, respectively. The difference was statistically significant （P〈0.05）. The difference of the early and delayed phase T/NT ratios in the normal control group was not statistically significant （1.09±0. 18 vs. 1.08±0.19, 〉0.05）. The difference in the benign group was statistically significant （1.77±1.36 vs. 1.28±0.83, P〈0.05）, whereas that of the breast cancer group was not statistically significant （3.98±3.11 vs. 3.04±2.46, P〉0.05）. The sensitivity of the semi-quantitative analysis in the diagnosis of breast cancer was 97.67%, the specificity was 81.82%, and the accuracy was 88.07%. The positive and negative values were 77.78% （42/54） and 98.18% （54/55）, respectively. Conclusion： Low dose ^99mTc-MIBI double-phase tomography imaging is an effective method to detect breast cancer, and has great clinical value in the differentiation of malignant and benign breast lesions.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第1期36-40,共5页
Chinese Journal of Clinical Oncology
基金
湖南省卫生厅资助项目(编号:06SK3057)资助~~
