摘要
目的常染色体显性遗传多囊肾病(ADPKD)患者有较高的颅内动脉瘤(IAs)的发病率,本研究拟利用3.0T磁共振血管造影(MRA)对ADPKD人群进行筛查及随访,观察ADPKD患者中未破裂颅内动脉瘤(UIAs)的大小变化。方法采用3.0T磁共振对30例ADPKD合并UIAs患者进行了MRA随访,所有患者两次检查至少间隔36个月。记录UIAs横径或上下径的最大值为动脉瘤大小。MRA随访UIAs增大的标准为:直径小于5mm的动脉瘤增大超过1mm;或者直径大于5mm的动脉瘤增大超过2mm。结果随访30例ADPKD合并IAs的患者中,共发现3例患者(10%)的UIAs符合MRA随访增大标准。所有随访患者第二次MRA检查前UIAs均未有过治疗或者破裂史,且UIAs直径均小于10mm,平均直径为(3.64±2.25)mm。结论 3.0T3D-TOF MRA适用于肾功能受损的ADPKD合并IAs患者进行随访。ADPKD患者UIAs的3年总体增大率没有明显高于一般人群。
Objective Autosomal dominant polycystic kidney disease （ADPKD） patients have an increased risk for intracranial aneurysms （IAs）. Our aim was to screen and follow up the unruptured intracranial aneurysms （UIAs） detected by 3.0 T magnetic resonance angiography （MRA） in patients with ADPKD in order to observe the growth of UIAs. Methods From 2011 to 2012, we followed up UIAs detected in 30 ADPKD patients who had two MRA examinations in more than 36 months interval. UIAs size was determined as longest diameter in transverse or vertical measurement. UIAs 〈5 mm with ≥1 mm growth and UIAs ≥5 mm with ≥2 mm growth were considered enlargement. Results 32 UIAs were found in 30 patients after 3 years follow up. All patients never had treatment or history of rupture before the second examination. The longest diameter of all follow-up UIAs was less than 10 mm and mean diameter was （3. 64±2.25） ram. Only 3 patients （10%） were considered enlargement. Conclusion 3.0 T 3D-TOF MRA was feasible for screening and follow up UIAs in ADPKD patients. The chance of enlargement and rupture of UIAs in ADPKD was not higher than general population.
出处
《医学影像学杂志》
2013年第1期4-8,共5页
Journal of Medical Imaging
基金
国家自然科学基金项目(No.81101044)
2012年第二军医大学军事医学专项基金
关键词
磁共振血管造影
常染色体显性遗传多囊肾病
颅内动脉瘤
随访
风险评估
Magnetic resonance angiography
Autosomal dominant polycystic kidney disease
Intracranial aneurysms
Follow up
Risk factor
