摘要
目的研究糖尿病对急性脑梗死生化型阿司匹林抵抗影响。方法选择急性脑梗死患者126例,根据有无糖尿病史分两组,两组均常规口服阿司匹林100mg,qd,1周后测定血小板聚集功能及血常规、血脂、血糖、C反应蛋白等指标。结果急性脑梗死阿司匹林抵抗(AR)发生率为28.2%(22/78),急性脑梗死合并糖尿病组AR发生率为27.1%(13/48),两组间血红蛋白、红细胞压积、血小板计数、体重指数差异均无统计学意义(P>0.05),脑梗死合并糖尿病组甘油三酯、低密度脂蛋白、C-反应蛋白、同型半胱氨酸高于脑梗死组(P<0.05),高密度脂蛋白低于脑梗死组(P<0.05)。结论糖尿病与脑梗死患者发生阿司匹林抵抗无关。
Objective To investigate the aspirin resistance in patients of acute cerebral intarction witn type z diabetes. Methods 48 patients of acute cerebral infarction with type 2 diabetes and another 78 patients without DM as control group were enrolled.Two groups of patients received 100 mg/d of aspirin for 7 days.Then platelet aggregation,blood glucose,blood routine test,blood lipids,C-reactive protein were detected respectively. Results The incidence of aspirin resistance in 78 patients of acute cerebral infarction patients was 28.2%,the incidence of aspirin resistance in 48 patients of acute cerebral infarction with type 2 diabetes was 27.1%,there was no significant difference between the two groups in Hb,Het,PLT,BMI,TG,LDL,CRP,Hcy in group of acute cerebral infarction with type 2 diabetes were higher than the controls （P 〈 O.05）,HDL were lower than the controls （P 〈0.05）. Conclusion Type 2 diabetes may he not associated with the aspirin resistance in patients of acute cerebral infarction.
出处
《中国医药科学》
2013年第1期193-194,共2页
China Medicine And Pharmacy
关键词
脑梗死
糖尿病
阿司匹林抵抗
Cerebral infarction
Type 2 diabetes
Aspirin resistance
