摘要
目的探讨仅亚麻酸（ALA）治疗对肥胖患者胰岛素敏感性的影响。方法2011年10月至2012年4月，于山西医科大学第二医院门诊就诊的16例肥胖患者采用ALA口服治疗8周，行前瞻性研究。治疗前后行口服葡萄糖耐量试验（OGTF）及胰岛素释放试验检查，采用稳态模型评估的胰岛素抵抗指数（HOMA．IR）和OGIT胰岛素曲线下面积（AUCI）评价其胰岛素敏感性，并测定空腹甘油三酯、血游离脂肪酸（FFA）、白细胞介素（IL）6及肿瘤坏死因子（TNF）Ot水平。结果肥胖组空腹胰岛素、HOMA．IR、甘油三酯、FFA、IL-6及TNF．q较正常对照组均明显增高（均P〈0．05）；肥胖组经ALA治疗后空腹胰岛素、甘油三酯、FFA、IL-6及TNF-a较治疗前明显降低（P〈0．05），HOMA—IR及AUCI较治疗前明显降低（HOMA—IR：1．8±0．2比1．2±0．3，P〈0．05；AUCI：1151±505比768±347，P〈0．05）。结论AIA治疗可显著改善肥胖患者的胰岛素敏感性，可能有助于2型糖尿病和动脉粥样硬化性心血管疾病的防治。
Objective To explore the effects of a-linolenic acid on insulin sensitivity in obese patients. Methods From October 2011 to April 2012, 16 patients received an oral dose of a-linolenic acid for 8 weeks. Oral glucose tolerance test（OGTF） and insulin releasing test were performed before and after treatment. Homeostasis model assessment insulin resistance （HOMA-IR）index and area under curve of insulin （AUCI）were calculated to evaluate the insulin sensitivity. The levels of serum triglyceride, free fatty acids （FFA）, interleukin-6 （IL-6） and tumor necrosis factor-alpha （TNF-a） were measured after an overnight fast. Results Obese patients had significantly elevated serum insulin, triglyceride, FFA, IL-6 and TNF-a versus the subjects in normal control group（ all P 〈 O. 05）. Obese patients were also more insulinresistant than normal subjects based on a higher HOMA-IR （ P 〈 0. 05 ） . Decreased serum insulin, triglyceride, FFA, IL-6 and TNF-a were observed after treatment. With the administration of a-linolenic acid, HOMA-IR and AUCI significantly decreased in obese patients （ HOMA-IR ： 1.8± 0. 2 vs 1.2 ± 0. 3, P 〈 0.05 ; AUCI ： 1151 ± 505 vs 768 ± 347, P 〈 0.05 ）. Conclusion a-linolenic acid increases peripheral insulin sensitivity in obese patients and it may aid the prevention and treatment of type 2 diabetes mellitus and atherosclerotic vascular diseases.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第2期132-134,共3页
National Medical Journal of China
关键词
肥胖症
仪亚麻酸
胰岛素敏感性
Obesity
Alpha-linolenic acid
Insulin sensitivity
