摘要
15 N标记水合肼是稳定同位素标记化合物合成过程中一种常用的强还原剂,广泛应用于同位素标记药类化合物的合成。本研究通过单因素实验考察了15 N标记水合肼合成过程中各因素对其收率的影响。结果表明,15 N标记水合肼的最佳合成条件为:次氯酸钠的有效氯含量为115～120g/L,氯化反应时间为30～40min,水解回流时间为7min,催化剂与尿素用量为m(催化剂)∶m(尿素)=1.0∶10.0。在此条件下,水合肼合成收率达76.1%,丰度为99.20%。
The 15N labeled hydrazine hydrate is a strong reducing agent in the synthesis procedure of stable isotope labeled compounds,and it has been widely used in the isotope-labeled pharmaceutical synthesis.The reaction conditions of 15N labeled hydrazine hydrate were mainly investigated by single-factor design,and the following optimized conditions were obtained： the concentration of available chlorine was 115-120 g/L,the chlorination reaction time was 30~40 min,the reflux time was 7 min,and the mass ratio of material was m（catalyst） ∶m（urea） =1.0∶10.0,and the yield of 15N labeled hydrazine hydrate was 76.1%,the abundance of 15N was 99.20%.
出处
《同位素》
CAS
2012年第4期204-208,共5页
Journal of Isotopes
基金
科技部十二五支撑项目(2012BAK25B03-15)
上海市科学技术委员会项目(上海化学试剂产业技术创新战略联盟:11DZ0511700)
