摘要
评估宫颈癌筛查方法,探讨少数民族地区宫颈病变发病情况。方法:2010年3月24日～2010年3月30日,在当地政府大力支持下,由当地妇幼保健院组织常住鄂尔多斯杭锦旗2013名年龄在25-65岁已婚有户籍的妇女进行宫颈癌筛查。采用第二代杂交捕获人乳头瘤病毒(HC-Ⅱ)和宫颈薄层液基细胞学(TCT)检测,对宫颈细胞异常和HC-Ⅱ阳性者进行阴道镜检查,阴道镜异常者行多点活检或宫颈管诊刮术,以病理学诊断为金标准。比较3种方法的检出率,评价TCT,HPV的诊断价值。结果:2013例受检者中,TCT异常患者258例,占12.82%;HPV-DNA阳性者,481例,占23.89%,在阴道镜下行多点活检,病理结果 CINⅠ以上者191例,占9.49%.TCT和HPV均阴性者,属于无病理改变。TCT(-),HPV(+)者中≥CINⅡ的检出率13.33%(2/15),TCT(+)和HPV(+)同时存在的病例中,CINⅡ的检出率最高占39.32%(46∕117),仅TCT(+)而HPV(-)者,占13.60%(8/59),8例均为CINⅡ,无原位癌和浸润癌发生。P<0.05差异有统计学意义。结论:持续的HR-HPV感染与宫颈病变的演进有关,TCT联合HC-Ⅱ是宫颈癌筛查最有效的方法,尤其对宫颈高度病变,可以有效的预防宫颈癌的发生。
Objective： Assessment of cervical cancer screening methods, in minority region in cervical disease incidence：Method： March 24, 2010 - 30 day in the local government support energetically below, by the local maternal and child health care hospital for years the organization of Erdos banner 2013 age in the 25 -65 years old married a domicile in women undergoing cervical screening, the cervical liquid based thin -layer cell （ TCT ） ; HC - II （ hybrid capture, two generation） for quantitative detection of cervical HPV - DNA content, on cervical cell abnormalities and HPV - DNA positive subjects undergoing eolposcopy, colposcopic abnormalities underwent multiple biopsy and endocervical curettage, the pathological diagnosis as the gold standard. Comparison of three methods of detection, evaluation of TCT, HPV diagnosis value. Resalts ： 2013 cases of abnormal TCT by pick- ing up, in 258 cases, accounting for 12.82% ; HPV - DNA positive, 481 cases, 23.89%, in a colposcopy downlink multiple bi- opsy. Pathological findings of more than CIN in 191 cases , accounting for 9.49% of;TCT and HPV were all negative, no patho- logical changes. TCT （ - ）, HPV （ ＋ ） ~CIN II in detection rate of 13.33% （2/15）, TCT and HPV （ ＋ ） exist at the same time case, CIN the highest detection rate accounted for 39.32% （46/117）, TCT （ ＋ ） ,HPV （ - ）, 13.60% （8/59）, 8 cases were CIN II, carcinoma in situ and invasive cancer without. There were statistically significant differences in P 〈 0.05. Conclusion ： High ris HPV infection is related to cervical lesion progress , cervical liquid based thin -layer cell （TCT） combined with HC -II （hybrid capture two generation） in cervical cancer screening are the most effective method, can be found in cervical lesion height, effective in the prevention of cervical cancer.
出处
《中国民族医药杂志》
2012年第12期65-68,共4页
Journal of Medicine and Pharmacy of Chinese Minorities
