摘要
目的比较先天性双侧输精管缺如（CBAVD）、精索静脉曲张（VC）、AZFc缺失这三种病因与相应对照周期卵胞浆内单精子注射（ICSI）治疗的结局。方法比较CBAVD组与非CBAVD的梗阻性无精子症（non—CBAVD组），VC组与非VC的严重少、弱精子症（non—VC组），AZFc缺失与非AZFc缺失的严重少弱精子症（non．AZFc组）行ICSI治疗的受精率、卵裂率、优质胚胎率、累积妊娠率以及其他相关指标。结果各组间的女方年龄差异无统计学意义。CBAVD组与non．CBAVD组比较，受精率为61．36％VS57．02％（P〉0．05），卵裂率100％VS99．61％（P〉0．05），优质胚胎率26．67％VS48．24％（P〈0．001），累积妊娠率52．94％VS80．56％（P〈0．05），CBAVD组优质胚胎率和累积妊娠率低于non-CBAVD组。VC组与non-VC组比较，受精率为60．48％VS66．03％（P〉0．05），卵裂率98．02％VS99．37％（P〉0．05），优质胚胎率40．40％VS38．79％（P〉0．05），累积妊娠率60．00％VS55．56％（P〉0．05），VC组受精率低于non—VC组，差异无统计学意义。AZFc组与non．AZFc组相比，受精率为57．14％VS64．92％（P〉0．05），卵裂率100％VS99．36％（P〉0．05），优质胚胎率36．36％vs41．33％（P〉0．05），累积妊娠率66．67％VS53．70％（P〉0．05），差异均无统计学意义。结论CBAVD男性ICSI优质胚胎率和累积妊娠率降低，VC和AZFc缺失对ICSI受精率、卵裂率、优质胚胎率和累积妊娠率无明显影响。
Objective To compare the ICSI treatment outcomes of congenital bilateral absence of the vas deferens, varicocele and AZFc microdeletion with corresponding control cycles. Methods The ICSI fertilization rate, cleavage rate, good quality embryo rate, cumulative pregnancy rate and other relevant parameters were comparatively analyzed between congenital bilateral absence of the vas deferens （CBAVD group） and non-CBAVD obstructive azoospermia （non-CBAVD group）, varicocele （VC group） and non- varicocele serious oligoasthenospermia （non- VC group）, AZFc microdeletion and non-AZFc microdeletion serious oligoasthenospermia （non-AZFc group）. Results There was no significant difference in the age of female among groups. Fertilization rates of the CBAVD group and the non-CBAVD group were 61.36% and 57.02% respectively（P〉 0.05）, cleavage rate were 100% and 99.61%（P〉 0.05）, good quality embryo rate were26.67% and 48.24% （P 〈0.001）, and cumulative pregnancy rate were 52.94% and 80.56% （P〈0.05）respectively. The qualified embryo rate and cumulative pregnancy rate were lower in CBAVD group than that of non-CBAVD. There were no statistical differences between VC group and non-VC group in fertilization rate （ 60.48% vs 66.03%, P〉0.05）, cleavage rate （98.02% vs 99.37%, P〉 0.05）, good quality embryo rate （40.40% vs 38.79%, P〉 0.05）, and cumulative pregnancy rate（ 60.00% vs 55.56%, P 〉0.05）. The VC group had lower fertilization rate, with no statistical differences. There were no statistical differences between AZFc group and non-AZFc group in fertilization rate （57.14% vs 64.92%, P〉 0.05）, cleavage rate （100% vs 99.36%, P〉 0.05）, good quality embryo rate （36.36% vs 41.33%, P〉 0.05） ,and and cumulative pregnancy rate（66.67% vs 53.70%, P〉 0.05）. Conclusion The qualified embryo rate and the cumulative pregnancy rate of CBAVD group were all decreased. No significant effect on the ICSI fertilization rate, cleavage rate, good quality embryo rate and cumulative pregnancy rate for patients with Varicocele and AZFc microdeletion.
出处
《中国男科学杂志》
CAS
CSCD
北大核心
2012年第11期33-36,44,共5页
Chinese Journal of Andrology
